妊娠糖尿病患者血清betatrophin水平变化及意义

发布时间：2018-03-15 17:26

本文选题：Betatrophin　切入点：妊娠糖尿病　出处：《安徽医学》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨妊娠糖尿病(GDM)患者空腹血清betatrophin水平及其与GDM发生发展过程中相关指标变化的相关性。方法收集2016年3~8月安徽医科大学第一附属医院妊娠24~32周孕妇120例,根据2010年国际糖尿病与妊娠小组推荐的GDM诊断标准,分为GDM组和正常对照组(NGT)各60例;根据体质指数(BMI)是否大于24 kg/m2,将两组患者分别分成体质量正常(GDM-NW,NGT-NW)亚组和超重(GDM-OW,NGT-OW)亚组,每亚组30例。应用酶联免疫吸附法(ELISA)检测各组空腹血清betatrophin浓度,并测定受试者身高、体质量、血脂指标;计算胰岛素抵抗指数(HOMA-IR)及胰岛β细胞功能指数(HOMA-β)。多元线性回归分析法分析空腹血清betatrophin与相关指标变化的相关性。结果血清betatrophin水平:GDM-OW组患者为(2 095.23±350.30)pg/m L,NGT-NW为(1 793.55±459.38)pg/m L,NGT-OW为(1 858.37±511.04)pg/m L,GDM-OW组血清betatrophin水平较NGT-OW亚组升高,差异有统计学意义(P0.05);空腹血清betatrophin与孕前BMI、空腹胰岛素、HOMA-IR、三酰甘油(TG)呈正相关;多元线性回归分析表明,TG是血清betatrophin独立影响因素。结论 Betatrophin与胰岛素抵抗相关,且参与了妊娠期间人体脂代谢,在GDM特别是超重的GDM患者疾病的发生发展中起重要作用。
[Abstract]:Objective to investigate the correlation between fasting serum betatrophin level and the changes of related indexes in the course of occurrence and development of GDM in patients with gestational diabetes mellitus (GDM). Methods from 2016 to August, 120 pregnant women at 32 weeks of pregnancy in the first affiliated Hospital of Anhui Medical University were collected. According to the GDM diagnostic criteria recommended by the international panel on diabetes mellitus and pregnancy in 2010, the two groups were divided into two groups: GDM group (n = 60) and normal control group (n = 60). According to the BMI > 24 kg / m ~ (2), the two groups were divided into two groups: normal weight group (GDM-NWNNGT-NW) group and overweight group (GDM-OWNGT-OW) subgroup. The fasting serum betatrophin concentration, height, body weight and blood lipid index were measured by Elisa in 30 cases of each subgroup. Insulin resistance index (HOMA-IRI) and islet 尾 -cell function index (HOMA- 尾) were calculated. Multivariate linear regression analysis was used to analyze the correlation between fasting serum betatrophin and related indexes. Results the level of serum betatrophin was 2 095.23 卤350.30 渭 g / m NGT-NW (1 793.55 卤459.38 渭 g / L NGT-OW) in patients with GDM-OW. The serum betatrophin level in the GDM-OW group was higher than that in the NGT-OW subgroup. There was a positive correlation between fasting serum betatrophin and pre-pregnancy BMI, fasting insulin HOMA-IRT, triglyceride TG.The multivariate linear regression analysis showed that triglyceride was an independent factor affecting serum betatrophin. Conclusion there is a correlation between Betatrophin and insulin resistance. It is involved in lipid metabolism during pregnancy, and plays an important role in the occurrence and development of GDM, especially in overweight GDM patients.
【作者单位】：安徽医科大学第一附属医院内分泌科;
【分类号】：R714.256

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