宫颈癌组织中人类黑色素瘤相关抗原A3表达变化及其意义

发布时间：2018-03-15 23:26

  本文选题：宫颈癌　切入点：宫颈上皮内瘤变　出处：《山东医药》2017年03期 　论文类型：期刊论文

【摘要】：目的观察宫颈癌组织中人类黑色素瘤相关抗原A3(MAGE-A3)的表达变化,分析其与肿瘤临床病理参数及预后的关系。方法收集宫颈癌组织76例、宫颈上皮内瘤变(CIN)组织40例、正常宫颈组织标本25例,采用免疫组化SP法检测MAGE-A3,分析MAGE-A3表达与患者年龄、FIGO分期、组织病理学分级、淋巴结转移及阴道残端癌累及的关系。收集70例宫颈癌患者的术后随访资料,采用Kaplan-Meier生存曲线分析MAGE-A3表达与患者预后的关系。结果宫颈癌组织、CIN组织、正常宫颈组织中MAGE-A3阳性表达率分别为53.94%、7.50%、0,组间两两相比,P均0.05。FIGO分期Ⅱa1期宫颈癌组织中MAGE-A3阳性表达率高于Ⅰ期者(P0.05)。病理分级为G1、G2、G3的宫颈癌组织中MAGE-A3阳性表达率逐渐增高(P均0.05)。有淋巴结转移的宫颈癌组织中MAGE-A3阳性表达率高于无淋巴结转移者(P0.05)。MAGE-A3低表达组患者5年生存率为78.1%(25/32),高表达组患者5年生存率为44.7%(17/38),两者相比,P0.05。结论宫颈癌组织中MAGE-A3阳性表达率高于CIN组织和正常宫颈组织;MAGE-A3高表达可能与宫颈癌的发生发展及不良预后密切相关。
[Abstract]:Objective to observe the expression of human melanoma associated antigen A3- MAGE-A3 in cervical carcinoma, and to analyze its relationship with clinicopathological parameters and prognosis. Methods 76 cases of cervical carcinoma and 40 cases of cervical intraepithelial neoplasia (CINs) were collected. Immunohistochemical SP method was used to detect MAGE-A3 in 25 cases of normal cervical tissue. The expression of MAGE-A3 and age and Figo stage, histopathological grade were analyzed. The relationship between lymph node metastasis and the involvement of vaginal stump carcinoma. The postoperative follow-up data of 70 patients with cervical cancer were collected, and the relationship between MAGE-A3 expression and prognosis was analyzed by Kaplan-Meier survival curve. The positive expression rates of MAGE-A3 in normal cervical tissues were 53.94 and 7.50, respectively. The positive expression rate of MAGE-A3 in cervical cancer tissues of stage 鈪，

本文编号：1617326