染色体多态性与复发性流产的关系研究

发布时间：2018-03-15 23:38

本文选题：染色体　切入点：多态性　出处：《实用妇产科杂志》2015年01期 　论文类型：期刊论文

【摘要】：目的:研究染色体多态性与复发性流产的关系。方法:对2011年1月至2013年6月在湖北省妇幼保健院就诊的681对(1362例)复发性流产的患者夫妇(复发性流产组),进行外周血淋巴细胞培养和染色体核型分析,同时选取373对(746例)无流产史,至少一胎足月分娩后的正常生育夫妇为对照组。结果:复发性流产组的夫妇中,染色体多态性检出率(9.03%,123/1362)高于对照组(2.41%,18/746),差异有统计学意义(P0.05)。复发性流产组中inv(9)、Yqh-、1qh+、D/G组、Yqh+、16qh+、9qh+的染色体多态性的检出率均高于对照组,差异均有统计学意义(P0.05),且复发性流产组中男性染色体多态性的检出率(11.31%,77/681)高于女性(6.75%,46/681),差异有统计学意义(P0.05)。结论:染色体多态性与复发性流产有一定关系,在复发性流产患者的病因分析中不应忽视染色体多态性的作用,男性染色体的多态性也是因素之一。
[Abstract]:Objective: to study the relationship between chromosome polymorphism and recurrent abortion. Methods: from January 2011 to June 2013 in Hubei Maternal and Child Health Hospital, 681 couples with recurrent abortion were selected. Peripheral blood lymphocyte culture and karyotype analysis were performed. At the same time 373 pairs (746 cases) with no history of abortion and normal couples with at least one full term delivery were selected as the control group. Results: among the couples in the recurrent abortion group, The detection rate of chromosome polymorphism was 9.03 / 1362) higher than that of the control group (2.41%, 18 / 746), the difference was statistically significant (P 0.05). The detection rate of chromosome polymorphism in the recurrent abortion group was higher than that in the control group (P < 0.05). The detection rate of chromosome polymorphism in the group of invocative abortion was higher than that in the control group (P < 0.05), and the detection rate of chromosome polymorphism in the group of invitatory abortion was higher than that in the control group (P < 0.05). The difference was statistically significant (P 0.05), and the detection rate of chromosome polymorphism in the recurrent abortion group was 11.31% 77 / 681), which was higher than that in the female group 6.75% / 681%. The difference was statistically significant (P 0.05). Conclusion: there is a certain relationship between the chromosome polymorphism and recurrent abortion. The role of chromosome polymorphism should not be ignored in the etiological analysis of recurrent abortion, and the male chromosome polymorphism is also one of the factors.
【作者单位】：湖北省妇幼保健院;
【分类号】：R714.21

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