自拟补肾活血煎剂联合雌孕激素序贯疗法对宫腔粘连术后子宫内膜影响的临床研究

发布时间：2018-03-16 07:31

本文选题：宫腔粘连　切入点：补肾活血煎剂　出处：《四川中医》2016年12期 　论文类型：期刊论文

【摘要】：目的:观察自拟补肾活血煎剂联合雌孕激素序贯疗法对宫腔粘连术后子宫内膜影响的临床疗效。方法:选择我院自2013年1月至2014年12月收治的120例宫腔粘连(IUA)患者,随机分为治疗组和对照组各60例,治疗组给予自拟补肾活血煎剂联合雌孕激素序贯疗法治疗,对照组给予雌孕激素序贯疗法治疗,均连续治疗3个月经周期,随访1年。结果:治疗3个月经周期后,对照组和治疗组对IUA患者月经情况改善的总有效率分别为61.82%和85.19%,差异有统计学意义(P0.05);与对照组相比,自拟补肾活血煎剂联合雌孕激素序贯疗法能显著升高临床症状评分(P0.05),显著升高患者中医证候变化的总有效率(P0.05),并能显著降低宫腔粘连程度评分(P0.05);两组治疗后子宫内膜厚度均较疗前增加,子宫动脉血流阻力指数(RI)及子宫动脉血流搏动指数(PI)较疗前下降,但组间比较无统计学差异(P0.05);随访1年,两组随机妊娠率分别为9.09%和18.51%差异显著(P0.05);且在治疗期间无不良反应发生。结论:补肾活血煎剂联合雌孕激素序贯疗法可明显增加患者的月经量并且改善其中医证候,疗效优于单用雌孕激素序贯疗法。治疗后两组患者子宫内膜厚度均较疗前增加,子宫动脉血流阻力指数及子宫动脉血流搏动指数均较疗前下降,可能与其改善子宫血流灌注量、促进子宫内膜修复有关。
[Abstract]:Objective: to observe the clinical effect of self-made decoction of tonifying kidney and activating blood circulation combined with estrogen and progesterone sequential therapy on endometrium after uterine cavity adhesion. Methods: from January 2013 to December 2014, 120 patients with intrauterine adhesion and IUAs were selected in our hospital. They were randomly divided into treatment group (n = 60) and control group (n = 60). The treatment group was treated with self-made decoction of tonifying kidney and activating blood circulation combined with the sequential therapy of estrogen and progesterone, while the control group was treated with sequential therapy of estrogen and progesterone for 3 consecutive menstrual cycles. Results: after 3 menstrual cycles, the total effective rates of menstrual improvement in IUA patients in control group and treatment group were 61.82% and 85.19, respectively (P 0.05). Bushen Huoxue decoction combined with estrogen and progesterone Sequential Therapy can significantly increase the clinical symptom score and the total effective rate of TCM syndromes change P0.05, and can significantly reduce the degree of intrauterine adhesion (P0.05N). The thickness of intima was higher than that before treatment. The uterine artery resistance index (RI) and uterine artery blood flow pulsatility index (PII) were lower than those before treatment, but there was no significant difference between the two groups (P 0.05). The random pregnancy rates of the two groups were 9.09% and 18.51%, respectively, and there were no adverse reactions during the treatment. Conclusion: Bushen Huoxue decoction combined with estrogen and progesterone Sequential Therapy can significantly increase the menstrual volume of patients and improve their TCM syndromes. After the treatment, the endometrial thickness of the two groups was increased, the uterine artery blood flow resistance index and uterine artery blood flow pulsatile index were lower than that before the treatment, which might improve the uterine blood flow perfusion, and the effect was better than that of the single estrogen and progesterone sequential therapy, and the uterine artery blood flow resistance index and uterine artery blood flow pulsatile index were decreased. Related to promoting endometrial repair.
【作者单位】：无锡市中医医院妇科;
【分类号】：R713.4

【相似文献】