抗感染干预对孕妇生殖道B族链球菌感染胎膜早破的影响

发布时间：2018-03-17 02:10

本文选题：抗感染　切入点：孕妇　出处：《中华医院感染学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨抗感染干预对孕妇生殖道B族链球菌(GBS)感染胎膜早破及对母婴预后的影响,以期为临床提供数据依据。方法选取2014年1月-2015年12月医院感染GBS的待分娩孕妇100例,随机单盲取法分为A、B组,另选同期未感染GBS孕妇50例为C组,A、B组均进行药敏试验,以观察当地GBS耐药性;A组选择药敏中敏感药物进行抗感染治疗至分娩,B、C组不予治疗;观察药敏试验结果,不同组别新生儿体质量、Apgar评分及母婴结局。结果 A、B组100例孕妇中对青霉素、克林霉素敏感率均90.00%,A组50例孕妇采用青霉素抗感染治疗,其余13例为青霉素过敏孕妇,采用克林霉素抗感染治疗;三组新生儿体质量比较,差异无统计学意义,B组新生儿1min及5min Apgar低于A、C组(P0.05);三组产妇产褥感染、宫内感染、羊水污染、产后出血发生率比较,差异无统计学意义;B组胎膜早破、剖宫产发生率高于A、C组(P0.05);三组新生儿胎儿窘迫、早产发生率比较,差异无统计学意义,B组新生儿肺炎及窒息发生率高于A、C组(P0.05)。结论孕妇生殖道GBS可增加胎膜早破、母婴不良结局,通过抗感染治疗,可降低胎膜早破发生率,改善母婴不良结局。
[Abstract]:Objective to investigate the effect of anti-infection intervention on premature rupture of fetal membrane and maternal and infant prognosis in pregnant women with Group B streptococcus B infection. Methods 100 pregnant women with GBS infection in hospital from January 2014 to December 2015 were selected. 50 pregnant women with uninfected GBS were randomly divided into two groups: group C (n = 50) and group A (n = 50). The drug sensitivity test was performed in group A (n = 50). The drug resistance of group A was compared with that of group A (n = 10). The drug sensitivity of group A was selected for anti-infection treatment until delivery without treatment in group B (n = 50). Results in group A, 100 pregnant women were treated with penicillin and clindamycin sensitivity rate of 90. 00g. 50 pregnant women in group A were treated with penicillin antiinfective therapy. The other 13 pregnant women with penicillin allergy were treated with clindamycin anti-infective therapy, the body weight of newborns in group B was significantly lower than that in group A (1 min and 5 min) than that in group C (P 0.05), puerperal infection, intrauterine infection and amniotic fluid contamination were observed in three groups. There was no significant difference in the incidence of postpartum hemorrhage and the incidence of cesarean section in group B was higher than that in group A (P 0.05), and the incidence of fetal distress and premature delivery in group B was higher than that in group A (P 0.05). The incidence of neonatal pneumonia and asphyxia in group B was higher than that in group A (P 0.05). Conclusion GBS in the reproductive tract of pregnant women can increase premature rupture of membranes and adverse outcome of mother and child. The rate of premature rupture of membranes can be reduced and the adverse outcome of mother and infant can be improved by anti-infection treatment.
【作者单位】：郑州大学附属医院南阳市中心医院消毒供应中心二部;郑州大学附属医院南阳市中心医院妇二科;郑州大学附属医院南阳市中心医院妇三科;
【基金】：河南省杰出人才创新基金资助项目(0524157309)
【分类号】：R714.433

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