奈达铂联合紫杉醇注射液对卵巢癌手术患者ROMA指数和HE4水平的影响

发布时间：2018-03-17 15:37

本文选题：奥沙利铂　切入点：紫杉醇注射液　出处：《现代生物医学进展》2016年29期 　论文类型：期刊论文

【摘要】：目的:探讨奈达铂联合紫杉醇注射液对卵巢癌术后患者ROMA指数、HE4水平的影响及临床疗效。方法:选取我院收治的卵巢癌术后患者70例,随机分为实验组和对照组,每组35例。对照组采用紫杉醇注射液治疗;实验组在对照组基础上联合奈达铂注射液治疗。观察并比较治疗前后两组患者ROMA指数、血清CA125和HE4水平、生存期、临床疗效及不良反应情况。结果:与治疗前相比,治疗后两组患者ROMA指数、血清CA125及HE4水平均下降,差异具有统计学意义(P0.05);与对照组比较,实验组患者治疗后ROMA指数、血清HE4及CA125水平较低,差异具有统计学意义(P0.05);与对照组比较,实验组患者生存期明显延长,差异具有统计学意义(P0.05)。结论:奈达铂联合紫杉醇注射液治疗卵巢癌具有显著的临床疗效,能够降低ROMA指数和血清CA125、HE4水平,而且毒副作用较小,可在临床进一步推广应用。
[Abstract]:Objective: to investigate the effect of neidplatin combined with paclitaxel injection on the level of ROMA index and clinical efficacy in patients with ovarian cancer after operation. Methods: 70 patients with ovarian cancer treated in our hospital were randomly divided into experimental group and control group. 35 patients in each group were treated with paclitaxel injection in the control group, and the patients in the experimental group were treated with nedaplatin injection on the basis of the control group. The ROMA index, serum CA125 and HE4 levels, survival time of the two groups were observed and compared before and after treatment. Results: compared with before treatment, the ROMA index, serum CA125 and HE4 levels of the two groups decreased, and the difference was statistically significant (P 0.05), and compared with the control group, the ROMA index of the patients in the experimental group after treatment was lower than that in the control group. The levels of serum HE4 and CA125 were lower, the difference was statistically significant (P 0.05), compared with the control group, the survival time of the patients in the experimental group was significantly longer than that in the control group. Conclusion: nedaplatin combined with paclitaxel injection is effective in the treatment of ovarian cancer. It can reduce the ROMA index and serum CA125HE4 level, and the side effects are small, so it can be popularized in clinic.
【作者单位】：湖北医药学院附属随州医院妇科;
【基金】：湖北省自然科学基金项目(2009CDA060)
【分类号】：R737.31

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