光动力治疗宫颈高危HPV潜伏感染疗效观察

发布时间：2018-03-18 04:19

本文选题：-氨基酮戊酸光动力　切入点：人乳头瘤病毒　出处：《中国皮肤性病学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的观察5-氨基酮戊酸光动力治疗宫颈高危型HPV(HR-HPV)感染的临床疗效和安全性。方法将入组的80例宫颈HR-HPV感染患者随机分为两组,治疗组42例,予20%ALA敷药4h后用635nm红光照射30min,1周1次,共3次,治疗结束后3,6,12个月检测HPV-DNA,对照组38例,不进行任何治疗,直接进行随访。比较两组检测结果及不良反应。结果治疗组在第3个月随访时有28例HRHPV转阴,6个月为31例,12个月时增加1例转阴,但有1例患者再次出现转阳,总转阴率为73.81%。对照组3,6,12个月随访时分别有6例,8例,11例转阴,总转阴率为28.95%。治疗组转阴率明显高于对照组,差异有统计学意义(P0.01)。治疗组患者出现轻度灼热、疼痛、分泌物增多等,未见严重不良反应。结论 5-氨基酮戊酸光动力治疗宫颈HR-HPV感染安全、有效。
[Abstract]:Objective to observe the clinical efficacy and safety of 5-aminolevulinic acid photodynamic therapy for high-risk cervical HPV-HR-HPV-HPV.Methods 80 patients with cervical HR-HPV infection were randomly divided into two groups: treatment group (n = 42). After being treated with 20ALA for 4 hours, 635nm red light was irradiated once a week for 30 min for a total of 3 times. HPV-DNA-HPV-DNAwere detected at the end of 3 weeks and 12 months after treatment, while 38 cases in the control group were not treated with any treatment. Results in the treatment group, 28 cases of HRHPV turned negative at the third month follow-up, 31 cases at 6 months, and 1 case turned negative at 12 months. The total negative conversion rate was 73.81%. In the control group, there were 6 cases, 8 cases or 11 cases turned negative, and the total rate of negative conversion was 28.95%. The negative conversion rate in the treatment group was significantly higher than that in the control group, and the difference was statistically significant (P 0.01). The patients in the treatment group had mild burning heat and pain, and the patients in the treatment group had mild burn and pain, and the total negative conversion rate in the treatment group was significantly higher than that in the control group. Conclusion 5-aminolevulinic acid photodynamic therapy for cervical HR-HPV infection is safe and effective.
【作者单位】：珠海市第二人民医院皮肤科;珠海市第二人民医院妇科;珠海市金湾区妇幼保健院;
【分类号】：R737.33

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