低剂量克罗米芬促排卵的优势

发布时间：2018-03-18 15:40

本文选题：低剂量　切入点：克罗米芬　出处：《现代妇产科进展》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨低剂量克罗米芬(CC)用于女性促排卵治疗的优势。方法:收集行促排卵治疗的女性188例,随机分为常规量组(CC 50mg/d)和低剂量组(CC 25mg/d),患者于月经周期第5天开始服药,第10天检测血清FSH、LH、E2值,经阴道B超监测卵泡发育和子宫内膜情况。比较两组HCG日Gn使用剂量、Gn使用天数、卵泡大小、排卵数及取消周期数。结果:患者的BMI均较高,属于超重。两组患者的年龄、BMI、基础内分泌(FSH、LH、E2、T)水平比较,差异均无统计学意义(P0.05)。与基础状态相比,用药5天后低剂量组的FSH升高不明显(P=0.69),常规量组FSH明显升高(P=0.000);两组LH及E2水平较基础状态均明显升高(P=0.000),但两组无明显差异(P0.05)。用药5天及HCG日时,低剂量组的子宫内膜厚度均明显高于常规量组(P=0.000);用药5天后低剂量组的优势卵泡直径明显大于常规量组(P=0.000),但HCG日两组的成熟卵泡直径无明显差异(P=0.56);HCG日低剂量组Gn使用剂量、使用天数及卵泡数明显少于常规量组(P=0.004;P=0.000);低剂量组无取消周期,常规量组有5个取消周期。结论:低剂量CC的促排卵效果与常规剂量相同,同时降低对子宫内膜厚度的影响及多卵泡发育的风险,副作用低,有重要的临床应用价值。
[Abstract]:Objective: to investigate the advantage of low dose clomiphene in the treatment of female ovulation. Methods: 188 women who were treated with ovulation were randomly divided into two groups: normal dose group (CC50 mg / d) and low dose group (CC25 mg / dD). The patients began taking drugs on the 5th day of menstrual cycle. On the 10th day, serum FSH LHN E 2, follicle development and endometrium were monitored by transvaginal ultrasound. The days of use, follicle size, ovulation number and cancellation period of HCG were compared between the two groups. Results: the BMI of the patients was higher than that of the control group. There was no significant difference between the two groups in the levels of BMI, FSHLHN, E2T, and the basic state of the two groups (P 0.05, P < 0.05), but no significant difference was found between the two groups (P < 0.05), but no significant difference was found between the two groups (P < 0.05). After 5 days of administration, the increase of FSH in the low dose group was not significant, but that in the routine dose group was significantly higher than that in the normal dose group, and the levels of LH and E2 in the two groups were significantly higher than those in the basic state, but there was no significant difference between the two groups on the 5th day and the HCG day, but there was no significant difference between the two groups. The endometrial thickness in the low dose group was significantly higher than that in the conventional dose group, and the dominant follicle diameter in the low dose group was significantly larger than that in the conventional dose group after 5 days, but there was no significant difference in the diameter of mature follicle between the two groups on the HCG day. The days of use and the number of follicles were significantly less than those in the routine dose group, but there was no cancellation period in the low dose group and five cancellations in the conventional dose group. Conclusion: the ovulation induction effect of low dose CC is the same as that of conventional dose. At the same time, the effects on endometrial thickness and the risk of multiple follicle development are reduced, and the side effects are low, which has important clinical application value.
【作者单位】：潍坊市人民医院生殖医学科;
【分类号】：R711.6

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