血清HE4及CA125对子宫内膜癌宫外转移的预测价值

发布时间：2018-03-19 09:52

本文选题：人附睾分泌蛋白(HE)　切入点：CA　出处：《现代妇产科进展》2015年11期 　论文类型：期刊论文

【摘要】：目的:评估术前血清HE4和CA125联合检测在子宫内膜癌(EC)的子宫外转移的诊断价值。方法:回顾分析327例EC患者的临床病理资料,检测血清HE4和CA125水平,分析HE4及CA125与临床病理参数的关系,计算诊断评价指标,绘制受试者工作特征(ROC)曲线,计算AUC值。结果:患者血清HE4和CA125水平与病灶范围大小、肌层浸润深度、肿瘤分化程度、临床分期、有无子宫外转移等有关,差异有统计学意义(P0.01)。血清HE4、CA125单项检测子宫外转移时,HE4敏感度最高,为57.81%,联合诊断能显著提高敏感度达79.68%。两项单独检测的ROC-AUC值分别为0.740、0.714,而联合诊断的ROC-AUC值为0.810,差异有统计学意义(P0.001)。结论:血清HE4和CA125联合预测EC患者的子宫外转移比单项检测更具优势。
[Abstract]:Objective: to evaluate the diagnostic value of preoperative combined detection of serum HE4 and CA125 in extrauterine metastasis of endometrial carcinoma. Methods: the clinicopathological data of 327 patients with EC were retrospectively analyzed and the levels of serum HE4 and CA125 were measured. The relationship between HE4, CA125 and clinicopathological parameters was analyzed, the diagnostic evaluation index was calculated, the operating characteristic curve was drawn, and the AUC value was calculated. Results: the serum HE4 and CA125 levels were correlated with the size of the lesion, the depth of myometrial infiltration, and the degree of tumor differentiation. The clinical stage was related to the presence of extrauterine metastasis, and the difference was statistically significant (P 0.01). The sensitivity of HE4 was the highest when serum HE4 + CA125 was used to detect extrauterine metastasis. For 57.81%, the sensitivity of combined diagnosis was 79.68.The ROC-AUC value of two separate tests was 0.7400.74, while the ROC-AUC value of combined diagnosis was 0.810, the difference was statistically significant (P0.0010.Conclusion: serum HE4 combined with CA125 can predict extrauterine metastasis ratio of EC patients. Single detection has more advantages.
【作者单位】：天津医科大学;天津市中心妇产科医院;
【分类号】：R737.33

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