米索前列醇不同给药方式终止中期妊娠的临床疗效及安全性研究

发布时间：2018-03-19 23:16

本文选题：米非司酮　切入点：米索前列醇　出处：《中国临床药理学杂志》2015年22期 　论文类型：期刊论文

【摘要】：目的探讨米索前列醇不同给药方式终止中期妊娠的临床疗效及安全性。方法 66例中期妊娠要求终止妊娠的孕妇随机分为对照组31例和试验组35例。试验组口服米非司酮100 mg·d-1,连服2 d,第3天晨起阴道内放置米索前列醇0.6 mg,如未分娩,则每12 h给药0.4 mg,重复不超过4次;对照组口服米非司酮100 mg·d-1,连服2 d,第3天晨起空腹口服米索前列醇0.4 mg,如未分娩,则每3 h给药0.4 mg,重复不超过4次。比较2组患者的总有效率、引产时间、产后出血量、阴道出血时间及米索前列醇用量。结果对照组总有效率为93.54%,试验组为100.00%(P0.05)。试验组引产时间、产后2 h出血量及米索前列醇用量显著低于对照组(P0.05),阴道出血时间差异无统计学意义(P0.05)。试验组终止妊娠期间发生恶心呕吐13例,发热2例,皮疹1例;对照组发生恶心呕吐12例,发热1例,2组不良反应发生率差异无统计学意义(P0.05)。结论米非司酮联合米索前列醇终止中期妊娠临床疗效确切,且经阴道给药效果较好。
[Abstract]:Objective to investigate the clinical efficacy and safety of misoprostol in terminating pregnancy in the second trimester. Methods 66 pregnant women who requested termination of pregnancy in the second trimester were randomly divided into control group (31 cases) and trial group (35 cases). Mifepristone 100 mg 路d -1 for 2 days, and vaginal misoprostol 0.6 mg from the morning of the third day, if not in labor, The control group took mifepristone 100 mg 路d -1 orally for 2 days, and then took misoprostol 0.4 mg / g on an empty stomach from the third day, if not in labor, and no more than 4 times repeated every 12 hours, and the control group took mifepristone 100 mg 路d -1 orally for 2 days. The total effective rate, induced labor time and postpartum bleeding volume were compared between the two groups. Results the total effective rate of the control group was 93.54, and that of the experimental group was 100.00g / kg P0.05.The time of induction of labor in the experimental group was 93.54 and 100.00g / kg respectively. The amount of bleeding and the dosage of misoprostol at 2 h postpartum were significantly lower than those in the control group (P 0.05), and there was no significant difference in the time of vaginal bleeding. There were 13 cases of nausea and vomiting, 2 cases of fever and 1 case of rash during the termination of pregnancy in the trial group. There were 12 cases of nausea and vomiting in the control group and 1 case of fever. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Mifepristone combined with misoprostol is effective in terminating the second trimester pregnancy, and the vaginal administration is better.
【作者单位】：浙江省兰溪市人民医院妇产科;
【基金】：浙江省兰溪市科技基金资助项目(2013C05)
【分类号】：R719.3

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