脾多肽注射液对宫颈癌新辅助化疗患者免疫功能影响及临床疗效观察

发布时间：2018-03-20 04:10

本文选题：宫颈肿瘤　切入点：放化疗　出处：《河北医科大学学报》2016年12期 　论文类型：期刊论文

【摘要】：目的观察脾多肽注射液对宫颈癌新辅助化疗患者免疫功能及临床疗效的影响。方法随机选取52例拟行新辅助化疗的宫颈癌患者分为对照组和研究组,对照组采用紫杉醇加奈达铂化疗,研究组在此基础上加用脾多肽注射液,比较2组近期疗效、不良反应和免疫功能的差异。结果研究组、对照组近期有效率分别为65.4%、61.5%,差异无统计学意义(P0.05)。研究组胃肠道反应、骨髓抑制、神经毒性和肝功能损害的发生率低于对照组,差异有统计学意义(P0.05)。化疗后研究组CD3~+、CD4~+、CD8~+和NK细胞明显高于对照组,差异有统计学意义(P0.05)。结论脾多肽注射液能提高宫颈癌新辅助化疗患者机体免疫功能,减轻化疗不良反应,具有减毒增效的作用。
[Abstract]:Objective to observe the effect of spleen polypeptide injection on immune function and clinical efficacy in patients with cervical cancer treated with neoadjuvant chemotherapy. Methods 52 patients with cervical cancer undergoing neoadjuvant chemotherapy were randomly divided into two groups: control group and study group. The control group was treated with paclitaxel plus nedaplatin, the study group was treated with spleen polypeptide injection, and the short-term efficacy, adverse reaction and immune function of the two groups were compared. The short-term effective rates of the control group were 65.4 and 61.5, respectively. The incidence of gastrointestinal reaction, bone marrow suppression, neurotoxicity and liver function damage in the study group was lower than that in the control group. The difference was statistically significant (P 0.05). The CD3 ~ + CD4 ~ + CD8 ~ and NK cells in the study group were significantly higher than those in the control group (P 0.05). Conclusion spleen polypeptide injection can improve the immune function of patients with cervical cancer neoadjuvant chemotherapy and alleviate the adverse effects of chemotherapy. It has the effect of reducing toxicity and increasing efficiency.
【作者单位】：河北省人民医院妇一科;河北省人民医院核医学科;河北省人民医院肿瘤二科;
【基金】：河北省医学科学研究重点课题(ZD20140203)
【分类号】：R737.33

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