常染色体平衡易位携带者控制性促排卵周期卵巢反应性分析

发布时间：2018-03-24 19:37

本文选题：染色体平衡易位　切入点：控制性促排卵(COS)　出处：《中华生殖与避孕杂志》2017年05期

【摘要】：目的探讨常染色体平衡易位及类型对胚胎植入前遗传学诊断(PGD)周期控制性促排卵(COS)中卵巢反应性的影响。方法回顾性分析379对染色体平衡易位夫妇行PGD的426个COS周期,其中男方正常女方为平衡易位携带者182个周期(研究组,A组),包括罗氏易位44个周期(A1组),相互易位138个周期(A2组);女方正常男方为平衡易位携带者244个周期(对照组,B组),包括罗氏易位65个周期(B1组),相互易位179个周期(B2组)。比较各组间COS中女方卵巢反应性指标。结果研究组与对照组间年龄、体质量指数(BMI)、基础内分泌(FSH、E2、LH)、窦卵泡数(AFC)、促性腺激素(Gn)用量和使用时间、第2日和第3日胚胎数、囊胚数、卵子成熟率、囊胚形成率等均无统计学差异(P0.05);A组h CG注射日E2水平、正常信号囊胚数[(5 469.8±2 365.1)ng/L,1.4±1.4]均显著低于B组[(6 033.3±2 587.5)ng/L,1.8±1.8](P0.05),A组取卵数、MII卵子数、形成囊胚数均低于B组,但是无统计学差异(P0.05);A1组h CG注射日E2水平、正常信号囊胚数[(5 573.2±2 146.1)ng/L,1.5±1.5]显著低于B1组[(6 565.0±2 961.1)ng/L,2.8±2.2](P0.05);A2组取卵数(14.6±6.6)显著低于B2组(16.5±6.7)(P0.05)。结论 (1)女方常染色体平衡易位可能影响COS中卵巢反应性;(2)女方罗氏易位形成平衡或正常胚胎几率低于男方罗氏易位者。
[Abstract]:Objective to investigate the effect of autosomal balanced translocation and its type on ovarian reactivity in preimplantation genetic diagnosis of controlled ovulation promoting ovulation (COSs). Methods 426 COS cycles of PGD were analyzed retrospectively in 379 pairs of couples with balanced chromosomal translocation. Of these, the normal male partner was a balanced translocation carrier for 182 cycles (study group A, including 44 cycles of Roche translocation, group A 1, reciprocal transposition of 138 cycles, group A 2, and the normal husband of the woman for 244 cycles of balanced translocation carrier (P < 0.05). Group B of control group, including 65 cycles of Roche translocation group B 1 and 179 cycles of B 2 group translocated with each other, were compared with each other in the indexes of female ovarian reactivity in COS. Results the age of the study group was compared with that of the control group. There was no statistical difference in body mass index (BMIA), basal endocrine FSHE2LHN, antral follicle number (AFCU), gonadotropin (Gnn) usage, the number of embryos on the 2nd and 3rd day, blastocyst number, oocyte maturation rate, blastocyst formation rate and so on. There was no statistical difference in E2 level on the day of hCG injection in group P0.05A. The number of normal signal blastocysts [5 469.8 卤2 365.1 ng / L 1 4 卤1 4] was significantly lower than that of group B [6 033.3 卤2 587.5 ng / L 1. 8 卤1. 8] P 0. 05 ng / L 1. 8 卤1. 8; the number of blastocysts formed in group A was lower than that in group B, but there was no statistical difference in E2 level on the day of CG injection in group P0. 05. The number of normal signal blastocysts [5 573.2 卤2 146.1 ng / L 1. 5 卤1 5] was significantly lower than that of group B1 [6 565.0 卤2 961.1 ng / L 2 2] P0.05G / L 2.8 卤2 2) significantly lower than that of group B2 (16.5 卤6. 7 P0. 05). Conclusion the autosomal chromosome balance translocation of female side may affect the ovarian reactivity in COS. The chance of embryo translocation was lower than that of male Roche translocation.
【作者单位】：郑州大学第一附属医院生殖医学中心;
【分类号】：R714.8

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