体内胰岛素水平与子宫内膜癌发生关系的探讨

发布时间：2018-03-25 09:49

本文选题：胰岛素　切入点：子宫内膜癌　出处：《癌症进展》2016年09期

【摘要】：目的探讨体内胰岛素水平与子宫内膜癌发生发展的关系。方法选取48例子宫内膜癌患者(研究组)和50例健康查体的女性(对照组),观察记录两组患者的临床指标,包括年龄、绝经年龄、体质量、腰围、月经史、孕产史、既往史(糖尿病、高血压等)、类固醇激素的使用情况等,并检测两组患者空腹血清C肽、胰岛素、雌二醇、雄烯二酮、雌酮、睾酮及性激素结合球蛋白(SHBG)水平。结果研究组的空腹血清C肽、胰岛素、雌酮、雌二醇、雄烯二酮及睾酮水平均高于对照组(P㩳0.05),SHBG水平低于对照组(P㩳0.05)。血清C肽及胰岛素检测水平与雌酮、雌二醇、雄烯二酮及睾酮水平呈正相关,与SHBG水平呈负相关。结论子宫内膜癌发病的原因可能是胰岛素对体内性激素产生负面影响。
[Abstract]:Objective to investigate the relationship between insulin level in vivo and the occurrence and development of endometrial carcinoma. Methods 48 patients with endometrial carcinoma (study group) and 50 healthy women (control group) were selected to observe and record the clinical indexes, including age, of the two groups. Postmenopausal age, body mass, waist circumference, menstrual history, pregnancy history, previous history (diabetes, hypertension, etc., steroid use, etc.). Fasting serum C-peptide, insulin, estradiol, androstenedione, estradiol, estradiol, estradiol, estradiol, estradiol, estradiol, estradiol, estradiol, estradiol, etc. Results the fasting serum levels of C peptide, insulin, estradiol, estradiol, androstenedione and testosterone in the study group were higher than those in the control group. The level of SHBG in the control group was lower than that in the control group. Serum C-peptide and insulin levels were positively correlated with the levels of estradiol, estradiol, androstenedione and testosterone, and negatively correlated with SHBG levels. Conclusion the pathogenesis of endometrial carcinoma may be due to the negative effect of insulin on sex hormones in vivo.
【作者单位】：山东省临朐县人民医院妇产手术室;山东省临朐县人民医院产科;
【分类号】：R737.33

【相似文献】