血清促性腺激素平抑因子与卵巢储备功能的相关性研究

发布时间：2018-03-25 22:24

本文选题：促性腺激素平抑因子(Gn　切入点：SAF)　出处：《吉林大学》2017年硕士论文

【摘要】：目的:通过测定各类患者血清Gn SAF、AMH及性激素等指标,记录各类患者的年龄等临床资料,分析各指标间的相关性,探讨Gn SAF在预测卵巢储备功能的临床价值。方法:将卵巢功能不同的244例患者作为研究对象,按照分组标准分为卵巢高反应组111例、卵巢反应低下组73例、正常反应组60例。检测3组患者的基础FSH、LH、AMH、E2、及Gn SAF,记录3组患者的窦状卵泡数及年龄分别进行组间差异性分析,并做相关性分析。应用SPSS19.0软件分析三个组别血清Gn SAF有无差异,用spearman相关系数分析Gn SAF与其他指标间的相关性。结果:(1)血清Gn SAF水平在卵巢高反应组、卵巢低反应组及正常反应组之间差异无统计学意义(P0.05),卵巢高反应组的患者血清Gn SAF含量高于卵巢正常反应的患者血清Gn SAF和卵巢低反应组患者血清Gn SAF浓度,但差异性无统计学意义(P0.05);(2)AMH、年龄及基础激素指标在卵巢低反应组、卵巢高反应组及卵巢正常反应组之间差异有统计学意义(P0.01)。(3)AMH与血清FSH、年龄等有负相关性(r=-0.403,p=0.000;r=-0.053,P0.01),具有统计学意义,与LH水平、E2水平、AFC等有正相关性,有统计学意义。(4)血清Gn SAF水平与AMH水平、FSH水平、LH水、E2水平、AFC等指标相关性无统计学意义。结论:(1)血清Gn SAF水平与预测卵巢储备功能无相关性,需加大样本量排除其他影响因素进行深度研究。(2)AMH及AFC与年龄、FSH等各个指标均有显著相关性。(3)在预测卵巢功能方面,联合抗苗勒氏管激素及窦状卵泡数等多个指标能取得更好的效果。
[Abstract]:Objective: to record the age and other clinical data of patients by measuring serum GnSAFAMH and sex hormone, and to analyze the correlation between them. To explore the clinical value of Gn SAF in predicting ovarian reserve function. Methods: one hundred and forty-four patients with different ovarian function were divided into ovarian hyperreactive group (n = 111) and ovarian low response group (n = 73). 60 cases of normal response group. The basic FSHLHAMHU E2 and GnSAF were detected, and the number of antral follicles and age of the three groups were recorded, and the correlation analysis was made. The serum Gn SAF of the three groups was analyzed by SPSS19.0 software. The correlation between Gn SAF and other indexes was analyzed by spearman correlation coefficient. There was no significant difference between the ovarian low response group and the normal response group. The serum Gn SAF level in the ovarian hyperreactive group was higher than that in the ovarian normal reaction group and the ovarian low reaction group. The serum Gn SAF level in the ovarian hyperreactive group was higher than that in the ovarian normal response group. However, there was no significant difference in AMH between the two groups. There were significant differences in age and basal hormone levels between ovarian low response group, ovarian hyperactive group and ovarian normal response group. There was a negative correlation between AMH and FSHs in serum, age, age, etc. There was a significant difference between age and age, there was a significant difference between age and age, and there was a significant difference between the age and the age of P0. 403p0. 000r-0. 053. There was no significant correlation between serum Gn SAF level and AMH level, LH level, E2 level and AFC level. Conclusion there was no correlation between serum Gn SAF level and ovarian reserve function. It is necessary to increase the sample size and exclude other influencing factors for in-depth study. There is a significant correlation between AFS, AMH and AFC, etc.) in predicting ovarian function, The combination of anti-Mullerian tube hormone and antral follicle number can achieve better results.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R711.6

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