子宫颈鳞癌中RON表达及其与预后的关系

发布时间：2018-03-26 04:38

本文选题：子宫颈鳞状细胞癌　切入点：受体酪氨酸激酶RON　出处：《现代妇产科进展》2015年12期

【摘要】：目的:探讨子宫颈鳞癌中RON表达与临床病理指标的联系及其预后价值。方法:采用免疫组化法检测RON在子宫颈鳞癌、子宫颈上皮内瘤变及慢性宫颈炎中的表达情况及定位分布,分析其与临床病理因素的关系,同时综合临床病理资料及随访数据对子宫颈鳞癌患者进行预后分析。结果:RON蛋白在正常宫颈组织、CIN、宫颈鳞癌组织中的高表达率分别为10%、37.5%、69.6%。宫颈鳞癌组织中RON蛋白高表达与FIGO分期、淋巴结转移有关(P0.05),而与患者年龄及肿瘤的分化程度无关(P0.05)。Kaplan-Meier法进行单因素生存分析,RON蛋白表达阳性患者及阴性患者的无瘤生存期分别为(23.27±2.10)月、(37.33±2.30)月;Log-rank检验结果显示,两组患者的无瘤生存期比较,差异有统计学意义(χ2=13.510,P0.001)。结论:RON蛋白在宫颈癌的发生、发展、临床分期与淋巴结转移中发挥了重要作用,有望成为预测宫颈癌病情进展的一个潜在的分子标记物。
[Abstract]:Objective: to investigate the relationship between the expression of RON and clinicopathological indexes and its prognostic value in squamous cell carcinoma of the cervix. Methods: immunohistochemical method was used to detect the expression and localization of RON in cervical squamous cell carcinoma, cervical intraepithelial neoplasia and chronic cervicitis. The relationship between it and clinicopathological factors was analyzed. At the same time, the prognosis of patients with cervical squamous cell carcinoma was analyzed by combining clinicopathological data and follow-up data. Results the high expression rates of RON protein in normal cervical tissues and cervical squamous cell carcinoma tissues were 103.5g / kg and 69.6.The high expression of RON protein and FIGO staging were observed in cervical squamous cell carcinoma tissues. Lymph node metastasis was related to P0.05, but it was not related to age and tumor differentiation. Univariate survival analysis was performed by P0.05U. Kaplan-Meier method. The tumor-free survival time of positive and negative patients was 23.27 卤2.10 months and 37.33 卤2.30 months, respectively. The results of Log-rank test showed that: 1. The difference between the two groups in tumor-free survival was statistically significant (蠂 ~ 2 ~ (2) 13.510 ~ (10) P _ (0.001)). Conclusion: the proportion of Ron protein plays an important role in the occurrence, development, clinical stage and lymph node metastasis of cervical cancer. It is expected to be a potential molecular marker for predicting the progression of cervical cancer.
【作者单位】：中南大学湘雅医学院附属海口医院;
【分类号】：R737.33

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