甲功异常母亲对婴幼儿甲功的影响,早期干预治疗对其智力障碍的补偿作用

发布时间：2018-03-27 05:21

本文选题：甲功　切入点：智力障碍　出处：《中国地方病防治杂志》2017年01期

【摘要】：目的观察甲亢和甲减病人合并妊娠生产后,婴儿的甲功变化,智力异常,和早期干预治疗后对婴幼儿智力障碍的补偿作用。方法对2010-2016年在吉林市中心医院妇产科、内分泌科就诊的甲功异常的妊娠妇女,共151名,孕妇在G12和G24分别测FT3、FT4、TSH、TPO、TG-ab。婴儿在出生时,6个月,12个月,分别检查甲功五项和运动、智力评分。结果甲亢组和甲减组妊娠妇女经干预治疗G12和G24时,甲功趋于正常,FT_3、FT_4、TSH水平无明显差异。甲亢组婴儿出生时TSH明显升高,其水平与其他两组比较P0.05,差异有统计学意义,各组孕妇后代神经智力发育及运动评分的比较MDI和PDI,甲亢组MDI和PDI水平有所下降,但后期上升明显,各组有所差别,但无统计学意义。我们早期干涉后婴儿的甲功和神经智力发育及运动评分明显上升,与健康对照组无显著差异。结论孕母甲功异常可以影响子代的甲状腺功能,使子代的智能发育受影响。甲亢组不良妊娠明显增多,孕妇甲功异常的及时干预治疗,子代甲功的及时调整,可以子代的智力评分和运动评分绝对值上升,对其子代的智力障碍有补偿作用。
[Abstract]:Objective to observe the effect of hypothyroidism and hyperthyroidism combined with pregnancy on the changes of thyroid function, abnormal intelligence and compensatory effect on mental retardation of infants after early intervention. Methods Obstetrics and gynecology were performed in Jilin City Central Hospital from 2010 to 2016. A total of 151 pregnant women with dysthyroidism were examined in G12 and G24 for FT3FT4TPOTPOTG-ab.Infant was born, 6 months and 12 months, respectively. Results there was no significant difference in thyroid function between hyperthyroidism group and hypothyroidism group when treated with G12 and G24, but there was no significant difference in thyroid function between hyperthyroidism group and hypothyroidism group at birth, and the level of TSH in hyperthyroidism group was significantly higher than that in other two groups (P 0.05). Comparison of neurological intelligence development and motor scores in offspring of pregnant women in each group the levels of MDI and PDI in hyperthyroidism group decreased but increased significantly in the later period. However, there was no statistical significance. The scores of thyroid function and neurointelligence development and motor function of infants after early intervention were significantly higher than those of the healthy control group. Conclusion the abnormal maternal nail work may affect the thyroid function of the offspring. In the hyperthyroidism group, the abnormal thyroid function of pregnant women increased obviously, the intervention treatment in time, the timely adjustment of the thyroid work in the offspring, the absolute value of intelligence score and motor score of the offspring could be increased. It can compensate for the mental retardation of their offspring.
【作者单位】：吉林市中心医院内分泌科;吉林市新农合管理中心;
【分类号】：R714.256

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