孕妇阴道假丝酵母菌携带特征及其药敏检测

发布时间：2018-03-27 07:35

本文选题：孕期　切入点：阴道假丝酵母菌　出处：《现代预防医学》2015年23期

【摘要】：目的对海南地区女性孕期阴道假丝酵母菌进行病原学调查,进一步了解菌种分布情况及探讨相关危险因素,为防治妊娠女性合并外阴阴道假丝酵母菌病(VVC)的发生和优生优育提供理论依据。方法随机采集1 512例2010年6月-2013年12月在门诊产检的妊娠女性阴道分泌物进行假丝酵母菌培养及菌种鉴定,并对其病例进行统计,了解相关影响因素并进行统计学分析。结果 (1)女性孕期阴道假丝酵母菌总的分离率是36.5%,其中白假丝酵母菌47.1%,光滑假丝酵母菌27.5%,热带假丝酵母菌4.3%;晚孕期女性阴道假丝酵母菌携带率明显增加,高达49.3%。(2)分离出的白假丝酵母菌对两性霉素B、5氟胞嘧啶的敏感性分别为99.2%、98.5%,对伏立康唑、氟康唑和伊曲康唑的敏感程度不一;非白假丝酵母菌对两性霉素B、5氟胞嘧啶的敏感性均为100%,对唑类抗真菌药的敏感性普遍不高。(3)孕前VVC史、人流史、血糖异常史的OR值(95%CI)依次是17.3(11.67~25.67)、3.79(2.78~5.18)、21.9(14.58~32.94)。结论海南地区女性孕期阴道假丝酵母携带具有分离率高、菌群以白假丝酵母菌为主,非白色假丝酵母菌有上升的趋势的特征;分离株的耐药性较普遍。为防止对妊娠结局的不利影响,需要早期给予干预,合理选择抗真菌药物,并加强优生优育知识的宣讲。
[Abstract]:Objective to investigate the etiology of Candida vaginalis during pregnancy in Hainan, and to investigate the distribution of Candida vaginalis and its risk factors. To provide theoretical basis for the prevention and treatment of vulvovaginal candidiasis (VVCC) in pregnant women with vulvovaginal candidiasis. Methods A total of 1 512 cases of vaginal secretions of pregnant women from June 2010 to December 2013 were collected randomly for false birth. Culture and identification of mycelia, And make statistics on their cases, Results the total isolation rate of Candida vaginalis during pregnancy was 36.5%, including 47.1% of Candida albicans, 27.5m of Candida smooth, 4.3% of Candida tropicalis; The carrying rate of Candida cerevisiae increased significantly. The sensitivities of Candida albicans isolated to amphotericin Bn5 fluorocytosine were 99.2% and 98.5%, respectively, and the sensitivities to Veconazole, fluconazole and itraconazole were different. The sensitivity of non-Candida cerevisiae to amphotericin B _ (5) fluorocytosine was 100, and the sensitivity to antifungal agents of azolium was not high. (3) the history of VVC and abortion before pregnancy. The OR value (95 CI) of the history of abnormal blood glucose was 17.3C 11.6725.67C 3.792.785.18U 21.9U 14.5858.32.940.Conclusion the rate of isolation of Candida vaginalis during pregnancy in Hainan area is high, the bacteria group is mainly Candida albicans, and the non-white Candida cerevisiae has the characteristic of rising trend. In order to prevent the adverse effects on pregnancy outcome, early intervention should be given, antifungal drugs should be reasonably selected, and the knowledge of eugenics and eugenics should be strengthened.
【作者单位】：中南大学基础医学院免疫系;海南医学院热带医学与检验医学院;海南省干部疗养院;海南省屯昌县人民医院;
【基金】：国家自然科学基金资助(30760001,31260225)
【分类号】：R714.251;R446.5

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