青岛地区妇女人乳头瘤病毒感染与宫颈病变的关系研究

发布时间：2018-03-27 09:12

  本文选题：宫颈病变　切入点：人乳头瘤病毒　出处：《青岛大学》2014年硕士论文

【摘要】：目的本研究旨在调查分析青岛地区妇女人乳头瘤病毒感染的特点,以及HPV感染与妇女宫颈病变的关系,为该地区妇女宫颈病变的防治提供依据。 方法对青岛市妇女儿童医院妇科门诊2012年8月到2014年3月收集的793例宫颈拭子样本进行HPV分型检测。793例进行HPV检测的患者中有285例后期对宫颈可疑病变部位进行了组织病理学活检。对793例标本中检测出HPV亚型分布进行分析,并对285例患者的HPV感染情况和组织病理学结果进行对比分析。 结果在检测的793例标本中HPV阳性标本338例,阳性率为42.62%,检测到24种HPV亚型。其中单一HPV感染250例,占感染者的73.96%；双重感染68例,占20.12%；三重感染17例,占4.47%；四重感染3例,占0.89%。各种HPV亚型检出次数前五位的是HPV16. HPV58、HPV52、HPV56、HPV33,五种亚型在各种阳性亚型的检出率分别是HPV16C24.50%),HPV58(12.92%), HPV52(9.35%), HPV56(9.35%),HPV33(6.01%)。在发生宫颈病变的患者中随着病变级别的增高HPV的检出率明显增高，，CINⅠ级62.96%(35/54),CIN Ⅱ级78.38%(29/37),CINIⅢ级97.22%(35/36),Ca100%(8/8)。 结论①HPV16、58、52、56、33是青岛地区妇女感染居前五位的主要HPV亚型。②青岛地区妇女感染的HPV亚型的分布与国内地区具有相似性和差异性。③在发生宫颈病变的患者中随着病变级别的增高HPV的检出率明显增高。
[Abstract]:Objective to investigate and analyze the characteristics of human papillomavirus (HPV) infection in women in Qingdao and the relationship between HPV infection and cervical lesions in order to provide evidence for the prevention and treatment of cervical lesions in women in Qingdao. Methods from August 2012 to March 2014, 793 samples of cervical swabs collected from gynecological outpatient department of Qingdao Women's and Children's Hospital were detected by HPV typing. 285 of 793 patients with HPV were included in suspected cervical lesions in late stage. Histopathological biopsy was performed. The distribution of HPV subtypes in 793 specimens was analyzed. The results of HPV infection and histopathology in 285 patients were compared and analyzed. Results of the 793 samples, 338 were positive for HPV, the positive rate was 42.62 and 24 HPV subtypes were detected. Among them, 250 cases were single HPV infection (73.96%), 68 cases were double infection (20.12g), 17 cases were triple infection (4.47%), and 3 cases were quadruple infection. The first five HPV subtypes were HPV16. HPV58, HPV52, HPV56, HPV33, the positive rates of the five subtypes were HPV16C24.50, HPV5812.92, HPV529.35, HPV569.355.The detection rate of HPV in patients with cervical lesions increased significantly with the increase of pathological grade of cervix cervix. The detection rate of cin 鈪

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