Notch3、pS6在上皮性卵巢癌组织中的表达及其与临床预后的关系

发布时间：2018-03-27 12:52

本文选题：上皮性卵巢癌　切入点：Notch信号通路　出处：《华中科技大学学报(医学版)》2015年01期

【摘要】：目的探讨Notch3、pS6蛋白在上皮性卵巢癌组织中的表达及其与临床病理学特征及总生存期的关系。方法采用免疫组化法检测30例正常卵巢上皮组织、30例卵巢囊腺瘤以及120例上皮性卵巢癌组织中Notch3及pS6蛋白的表达。结果 Notch3、pS6蛋白在正常卵巢组织、良性卵巢囊腺瘤组织、上皮性卵巢癌组织中均有阳性表达,阳性率分别为16.7%、70.0%、91.7%和16.7%、76.7%、90.0%,上皮性卵巢癌中Notch3、pS6蛋白的表达显著高于正常卵巢组织及良性卵巢囊腺瘤组织(均P0.01),与临床分期、病理分级、组织类型、淋巴转移及腹水有关,与患者年龄无关。Notch3蛋白与pS6蛋白在上皮性卵巢癌中的表达呈正相关(rs=0.668,P0.01)。Notch3及pS6高表达组总生存期较短,低表达组的总生存期明显较长(χ2=41.479,P0.01)。Notch3和pS6高表达组腹水阳性率为82.1%,显著高于中表达组(51.9%)及低表达组(27.0%)(χ2=28.448,P0.01)。结论上皮性卵巢癌组织中Notch3、pS6蛋白的高表达与患者生存期(不良预后)密切相关,高表达Notch3及pS6患者总生存期缩短。
[Abstract]:Objective to investigate the expression of Notch3pS6 protein in epithelial ovarian carcinoma and its relationship with clinicopathological features and total survival. Methods 30 cases of ovarian cystadenoma and 120 cases of ovarian cystadenoma were detected by immunohistochemical method. Expression of Notch3 and pS6 proteins in epithelial ovarian carcinoma. Results Notch3pS6 protein was expressed in normal ovarian tissues. In benign ovarian cystadenoma and epithelial ovarian carcinoma, the positive rates were 71.7% and 16.77.76. 70.The expression of Notch3 pS6 protein in epithelial ovarian carcinoma was significantly higher than that in normal ovarian tissues and benign ovarian cystadenoma tissues (all P0.01, P 0.01), and the expression of Notch3 pS6 protein in epithelial ovarian carcinoma was significantly higher than that in normal ovarian tissues and benign ovarian cystadenoma tissues (P 0.01). Pathological grade, histological type, lymphatic metastasis and ascites were related to age. The expression of pS6 protein and Notch3 protein were positively correlated with the expression of pS6 protein in epithelial ovarian carcinoma. The total survival time of the low expression group was significantly longer (蠂 2 + 41.479U P0.01N. Notch3 and pS6 high expression group was 82.1%, significantly higher than that of the moderate expression group (51.9%)) and the low expression group (蠂 2 + 28.448% P 0.01). Conclusion the high expression of Notch3pS6 protein in epithelial ovarian carcinoma is closely related to the survival period (poor prognosis). The total survival time of patients with high expression of Notch3 and pS6 was shortened.
【作者单位】：广东医学院附属南山医院妇产科;南昌大学第一附属医院妇产科;河南省新乡市中心医院妇产科;珠海市第二人民医院妇产科;南昌大学第二附属医院妇产科;
【基金】：深圳市南山区科研基金资助项目(No.2013015)
【分类号】：R737.31

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