子宫内膜癌患者血清HE4、CA125水平变化及其意义

发布时间：2018-03-30 04:19

本文选题：子宫内膜癌　切入点：人附睾分泌蛋白　出处：《山东医药》2017年03期

【摘要】：目的观察子宫内膜癌患者血清人附睾分泌蛋白4(HE4)、糖类抗原125(CA125)水平变化,并探讨其临床意义。方法子宫内膜癌患者75例(病例组)、子宫良性疾病患者70例(对照组),采用ELISA法检测两组血清HE4,采用电化学发光免疫法检测血清CA125。分析血清HE4水平与CA125水平的相关性,探讨血清HE4、CA125水平与子宫内膜癌临床病理参数的关系,分析血清HE4、CA125检测对子宫内膜癌的诊断效能。结果病例组、对照组血清HE4水平分别为79.76、46.23 pmol/L,血清CA125水平分别为23.10、17.98 U/m L,病例组血清HE4水平高于对照组(P0.05)。病例组血清HE4、CA125水平呈正相关关系(r=0.367,P0.05)。子宫内膜癌患者血清HE4、CA125水平随肌层浸润深度、分期增加而逐渐升高(P均0.05);有淋巴结转移者、腹腔冲洗液或腹水中找到肿瘤细胞者血清HE4、CA125水平分别高于无淋巴结转移者和腹腔冲洗液或腹水中未找到肿瘤细胞者(P均0.05);血清HE4水平随患者年龄增加、肿瘤分化程度降低及绝经出现而升高(P均0.05)。血清HE4单项检测及HE4、CA125联合检测诊断子宫内膜癌的敏感度及准确率均高于CA125单项检测(P均0.05)。血清HE4检测诊断子宫内膜癌的受试者工作特征(ROC)曲线下面积为0.874,95%CI为0.819~0.928;血清CA125检测诊断子宫内膜癌的ROC曲线下面积为0.582,95%CI为0.488~0.675;HE4、CA125联合检测诊断子宫内膜癌的ROC曲线下面积为0.875,95%CI为0.820~0.929;HE4、CA125联合检测对子宫内膜癌的诊断效能更高。结论子宫内膜癌患者血清HE4水平升高,血清HE、CA125水平可能与子宫内膜癌的进展和患者预后有关;HE4检测对子宫内膜癌的诊断效能优于CA125检测,HE4、CA125联合检测可以为子宫内膜癌诊断提供更多的信息。
[Abstract]:Objective To observe the serum of patients with endometrial cancer epididymis protein 4 (HE4), carbohydrate antigen 125 (CA125) levels, and to explore its clinical significance. Methods 75 cases of endometrial cancer patients (case group), 70 patients with benign uterine diseases (control group), ELISA method was used to detect serum HE4 two groups. Chemiluminescence immunoassay detection serum CA125. correlation analysis of serum HE4 level and CA125 level by electrochemical, serum HE4, CA125 levels of endometrial carcinoma and the clinical pathological parameters, analysis of serum HE4, CA125 detection and diagnosis effect of endometrial carcinoma. Results the case group, serum HE4 level in the control group were 79.76,46.23 pmol/L, serum the level of CA125 were 23.10,17.98 U/m L cases, the serum level of HE4 was higher than that of the control group (P0.05 cases). The serum HE4, CA125 levels were positively correlated (r=0.367, P0.05). Endometrial cancer patients serum HE4, CA125 levels with muscle Infiltration depth, stage gradually increased (P; 0.05) with lymph node metastasis, ascites and peritoneal lavage fluid found in tumor cells of serum HE4, CA125 levels were higher than those without lymph node metastasis and peritoneal lavage fluid or ascites tumor cells were not found in the (P 0.05); the level of serum HE4 with the increase of the age of patients, tumor differentiation and reduce menopausal appear increased (P 0.05). Serum HE4 and HE4 CA125 single detection, combined detection in the diagnosis of endometrial cancer sensitivity and accuracy of CA125 were higher than that of single detection (P 0.05). Serum HE4 detection in diagnosis of endometrial cancer subjects work characteristic (ROC) area under the curve for 0.874,95%CI 0.819~0.928; ROC curve of serum CA125 detection in diagnosis of endometrial cancer is 0.582,95%CI 0.488~0.675; HE4, ROC curve below CA125 combined detection in the diagnosis of endometrial cancer product as 0.875,95%CI 0.820~ 0.929; HE4, CA125 combined detection for diagnosis of endometrial carcinoma was higher. Conclusion patients with endometrial cancer increased, serum HE4 levels of serum HE, CA125 levels may be related to endometrial cancer progression and prognosis; HE4 detection is better than CA125 for diagnosis of endometrial cancer detection, HE4, CA125 joint detection can endometrial cancer diagnosis to provide more information.

【作者单位】：无锡市妇幼保健院;
【分类号】：R737.33

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