表皮生长因子过表达与宫颈癌预后相关性Meta分析

发布时间：2018-03-30 14:24

本文选题：宫颈癌　切入点：表皮生长因子　出处：《中华肿瘤防治杂志》2015年16期

【摘要】：目的评价表皮生长因子受体(epidermal growth factor receptor,EGFR)过表达在宫颈癌预后中的价值,为抗EGFR靶向治疗提供理论依据。方法计算机检索PubMed和Embase数据库以及中国知网、维普和万方数据库中有关EGFR表达与宫颈癌的文献,采用Review Manager 4.3软件进行分析。EGFR过表达与淋巴结转移、临床分期和病理类型采用合并比值比(odds ratio,OR)及95%可信区间(confidence interval,CI)进行分析。总生存期(overall survival,OS)及无病生存期(disease free survival,DFS)采用风险比(hazard ratio,HR)及95%CI进行分析。结果入选20篇文献纳入研究,显示EGFR与淋巴结转移有关,OR=1.68,95%CI为1.16~2.44,P=0.006;与国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期有关,OR=1.66,95%CI为1.12~2.46,P=0.02;与病理类型有关,OR=4.79,95%CI为2.35~9.76,P0.001;与OS有关,HR=1.33,95%CI为1.15~1.53,P0.001;与DFS有关,HR=1.36,95%CI为1.12~1.65,P=0.002。EGFR与年龄无关,OR=1.20,95%CI为0.84~1.71,P=0.19。结论EGFR的过表达对淋巴结转移、OS及DFS有预测价值,可能是宫颈癌不良预后的预测因子,EGFR靶向治疗可考虑作为宫颈癌综合治疗的方法。
[Abstract]:Objective to evaluate the value of epidermal growth factor receptor (EGFR) overexpression in the prognosis of cervical cancer and to provide a theoretical basis for anti-#en2# targeted therapy. Review Manager 4.3 software was used to analyze the expression of EGFR and lymph node metastasis in the literature about EGFR expression and cervical cancer in Weip and Wanfang databases. The clinical stages and pathological types were analyzed by combining odds odds ratio (OR) and 95% confidence confidence confidence (CI). The total survival time and disease-free survival (DFS) were analyzed by risk ratio hazard ratio (hazard ratio) and 95%CI. Results 20 articles were included in the study. The results showed that EGFR was related to lymph node metastasis, OR1. 6895 CI was 1.162.44% P0. 006, and to the stage of International Federation of Gynecology and stestetrics Figo was 1. 12 卤2. 46% P0. 02; OR4. 79 95 CI was 2. 3535 9 / 7 6 P0.001CI; HR1. 333% 95 CI was 1. 15 ~ 1. 53% P 0.001; and DFS was 1. 369 95 CI = 1. 12 1 695 P 0.002. EGFR was not related to age. Conclusion: 0. 841. 71P0. 19Ci was 0.841.71P190.Conclusion. The overexpression of OSS and DFS in lymph node metastasis may be useful in predicting lymph node metastasis. EGFR targeted therapy may be a predictor of poor prognosis of cervical cancer.
【作者单位】：山东省肿瘤医院妇科;济南大学·山东省医学科学院医学与生命科学学院;
【基金】：山东省科技发展计划(2013YD18028)
【分类号】：R737.33

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