卵巢淋巴瘤和以淋巴结转移为主的卵巢癌临床特征比较

发布时间：2018-03-31 06:06

本文选题：卵巢淋巴瘤　切入点：卵巢癌　出处：《中国癌症杂志》2017年04期

【摘要】：背景与目的:卵巢淋巴瘤(ovarian lymphoma,OL)和以淋巴结转移为主的卵巢癌(ovarian cancer with bulk lymph node invasion,OC-BLN)常被相互误诊,该研究通过比较两者间临床特点,帮助鉴别。方法:回顾2008年11月—2016年1月复旦大学附属肿瘤医院和上海市第八人民医院共14例OL和14例OC-BLN的临床特征、影像学资料及实验室检查数据进行对比分析。结果:两组在年龄、症状、伴发腹水、发热、体重减轻和输尿管梗阻比率间差异无统计学意义,OL组卵巢肿块直径更大[(13.04±5.94)cm vs(7.78±6.38)cm,P=0.033]、实性肿瘤比率更高(85.71%vs 28.57%,P=0.006)。卵巢淋巴瘤患者血清LDH/CA125比值为7.66±8.03,高于卵巢癌组的0.31±0.27(P=0.009)。以LDH/CA125值作为卵巢淋巴瘤诊断指标,曲线下面积(area under the curve,AUC)可达0.952,如选取1作为临界值,灵敏度和特异度分别为91.7%和100%。结论:OL与OC-BLN存在的临床特征易混淆,但通过卵巢肿瘤表现和血清LDH/CA125值的比较可帮助鉴别诊断,从而更好地指导下一步的临床治疗。
[Abstract]:Background and objective: ovarian lymphoma (ovarian lymphoma, OL) and lymph node metastasis of ovarian cancer. (ovarian cancer with bulk lymph node invasion, OC-BLN) are often misdiagnosed, to help identify the study through the comparison between the clinical characteristics and clinical features. Methods: review of November 2008 - January 2016 in Tumour Hospital Affiliated to Fudan University and Shanghai Eighth People's Hospital, a total of 14 cases of OL and 14 cases of OC-BLN, imaging data and laboratory data were analyzed. Results: the two groups in age, symptoms, accompanied with ascites, fever, weight reduction between light and ureteral obstruction ratio have no statistical significance, OL group of ovarian masses larger diameter [(13.04 + 5.94) cm vs (7.78 + 6.38 cm, P=0.033]), a higher rate of solid tumors (85.71%vs 28.57%, P=0.006). Ovarian lymphoma patients serum LDH/CA125 ratio was 7.66 + 8.03, higher than that of ovarian cancer group 0.31 + 0.27 (P=0.009). With the LDH/CA125 value as the index for diagnosis of ovarian lymphoma, the area under the curve (area under the curve, AUC) up to 0.952, such as the selection of 1 as the critical value, the sensitivity and specificity were 91.7% and 100%. respectively. Conclusion: the clinical features of OL and OC-BLN are easily confused, but the tumor ovary and serum LDH/CA125 value comparison help the differential diagnosis, so as to better guide the clinical treatment of the next step.

【作者单位】：上海市第八人民医院妇产科;濉溪县中医院妇产科;复旦大学附属肿瘤医院肿瘤内科复旦大学上海医学院肿瘤学系;复旦大学附属肿瘤医院病理科复旦大学上海医学院肿瘤学系;复旦大学附属肿瘤医院影像科复旦大学上海医学院肿瘤学系;沈阳药科大学中药学院;复旦大学附属肿瘤医院妇瘤科复旦大学上海医学院肿瘤学系;
【基金】：上海市卫计委青年项目(20154Y0066) 国家自然科学基金青年项目(81400161,81101649)
【分类号】：R737.31

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