子宫内膜细胞取材器诊断慢性子宫内膜炎的价值

发布时间：2018-03-31 10:16

本文选题：慢性子宫内膜炎　切入点：CD38　出处：《山西医科大学》2014年硕士论文

【摘要】：目的研究子宫内膜细胞取材器诊断慢性子宫内膜炎的价值。方法（1）选取患者先行子宫内膜细胞采集器取样后行诊断性刮宫术取样。标本分为子宫内膜细胞取材器组和诊断性刮宫术组，，两组取材结果满意率的比较；（2）免疫组织化学方法测CD38、CD138均阳性时可诊断慢性子宫内膜炎。将子宫内膜细胞取材器组获取的标本分为HE染色法组与免疫组织化学染色法检测CD38、CD138组，两组病理结果诊断慢性子宫内膜炎阳性率的比较；（3）子宫内膜细胞取材器组和诊断性刮宫术组，行免疫组织化学染色法检测CD38、CD138，两组病理结果诊断慢性子宫内膜炎阳性率的比较。（1）、（2）、（3）采用配对四格表资料2检验。结果（1）诊刮术组取材满意率（92.5%）与取材器组取材满意率（88%）比较差异无统计学意义（2=1.64，P=0.2008）。（2）免疫组织化学染色法检测CD38、CD138组诊断阳性率（26.19%）与HE染色组诊断阳性率（3.57%）比较差异有统计学意义（2=36，P0.005）。（3）子宫内膜细胞取材器组诊断阳性率（26.19%）与诊刮术组诊断阳性率（27.38%）比较差异无统计学意义（2=0.083，P0.5）。结论（1）子宫内膜细胞取材器可取到满意的组织学标本；（2）采用免疫组织化学方法检测CD38联合CD138较传统HE染色法诊断慢性子宫内膜炎方法更具灵敏性和特异性；（3）子宫内膜细胞取材器所获标本对慢性子宫内膜炎诊断结果可靠、准确性较高。
[Abstract]:Objective to study the value of endometrial cell sampler in the diagnosis of chronic endometritis. Methods 1) the specimens were divided into two groups: endometrial cell sampling group and diagnostic curettage group. Comparison of satisfactory rate of results obtained from two groups: (2) Immunohistochemical method can diagnose chronic endometritis when CD38 + CD138 is positive. The specimens obtained from endometrial cells were divided into HE staining group and immunohistochemistry CD38 + CD138 group. A comparison of the positive rates of pathological results in the diagnosis of chronic endometritis: the endometrial cell sampling apparatus group and the diagnostic curettage group, Immunohistochemical staining was used to detect CD38 and CD138.The positive rates of CD38 and CD138were compared between the two groups in the diagnosis of chronic endometritis. Results 1) there was no significant difference in the satisfaction rate between the curettage group (92.5) and the sampler group (88%). There was no significant difference between the two groups. There was no significant difference between the two groups. (2) Immunohistochemical staining was used to detect the diagnostic positive rate of CD38 + CD138 group (26.19%) and HE staining group (3.57%). The positive rate of diagnosis in the endometrial cell sampling group was 26.19) and that in the curettage group was 27.38) there was no significant difference between the two groups. Conclusion 1) A satisfactory histological specimen can be obtained from endometrial cell sampler. The detection of CD38 combined with CD138 by immunohistochemical method is more sensitive and specific than the traditional HE staining method in the diagnosis of chronic endometritis. The specimens obtained from the endometrial cell extractor were reliable for the diagnosis of chronic endometritis. The accuracy is high.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.32

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