XPG基因遗传变异与上皮性卵巢癌铂类化疗预后相关性研究

发布时间：2018-03-31 11:38

  本文选题：XPG　切入点：tagSNPs　出处：《中国实用妇科与产科杂志》2015年03期

【摘要】：目的探讨XPG基因单核苷酸多态性(SNPs)与上皮性卵巢癌铂类化疗预后的关系。方法通过Haploview软件筛选出XPG基因9个标签SNPs(tag SNPs)。连接酶检测反应技术检测2002年3月至2009年12月在河北医科大学第四医院进行手术治疗的239例上皮性卵巢癌患者外周血DNA XPG基因9个tag SNPs的基因型频率分布情况。采用生存分析评估XPG基因SNPs与上皮性卵巢癌患者临床预后的关系。患者临床预后的判定指标包括患者对铂类化疗反应(TR)、疾病无进展生存期(PFS)和总生存期(OS)。结果统计学分析显示:XPG基因rs1047768C/T和rs2296147C/T多态可能与确诊时年龄≥50岁的卵巢癌患者临床预后相关。即与rs1047768 T/T基因型相比,rs1047768C等位基因降低了患者铂类抵抗、疾病复发和死亡的风险(TR:OR=0.49,95%CI 0.24~0.98;PFS:HR=0.57,95%CI 0.38~0.87;OS:HR=0.56,95%CI 0.34~0.94);与rs2296147 T/T基因型相比,rs2296147C等位基因降低上皮性卵巢癌患者疾病复发和死亡的风险(PFS:HR=0.63,95%CI 0.41~0.98;OS:HR=0.50,95%CI 0.28~0.87)。结论 XPG rs1047768C/T和rs2296147C/T多态可能是确诊时年龄≥50岁卵巢癌患者临床预后的分子标志物。
[Abstract]:Objective to investigate the relationship between XPG gene single nucleotide polymorphisms (SNPs) and the prognosis of platinum chemotherapy in epithelial ovarian cancer.Methods 9 XPG gene tags SNPs(tag SNPs were screened by Haploview software.The genotypes of DNA XPG gene 9 tag SNPs in peripheral blood of 239 patients with epithelial ovarian cancer treated in the fourth Hospital of Hebei Medical University from March 2002 to December 2009 were detected by ligase assay.Survival analysis was used to evaluate the relationship between XPG gene SNPs and clinical prognosis in patients with epithelial ovarian cancer.The clinical prognostic criteria included the response of patients to platinum chemotherapy, the progressive survival time (PFS) and the total survival time (TSA).Results the statistical analysis showed that the rs1047768C/T and rs2296147C/T polymorphisms of the 1: XPG gene might be related to the clinical prognosis of ovarian cancer patients aged more than 50 years at the time of diagnosis.Conclusion Polymorphism of XPG rs1047768C/T and rs2296147C/T may be molecular markers for clinical prognosis of ovarian cancer patients aged 鈮，

本文编号：1690574