辅助生殖技术中发生枯萎卵的影响因素

发布时间：2018-04-01 16:05

本文选题：辅助生殖技术　切入点：枯萎卵　出处：《南方医科大学学报》2017年07期

【摘要】：目的探究辅助生殖技术(ART)妊娠妇女中枯萎卵的发生率和影响因素。方法回顾性分析2012年1月~2015年12月在南方医科大学南方医院生殖中心行体外受精-胚胎移植临床妊娠共2378例,包括早期胚胎停育和同期单胎活产,其中胚胎停育根据有无胎芽分为胎芽组和枯萎卵组。比较枯萎卵组、胎芽组和活产组3组间基本信息,如女方年龄、男方年龄、体质量指数(BMI)、基础窦卵泡数(AFC)、基础卵泡刺激素(b FSH)、b FSH/b LH比值、不孕年限、促性腺激素(Gn)用量及Gn天数、人绒毛膜促性腺激素(h CG)注射日雌二醇值、移植日内膜厚度、获卵数、移植优胚率、移植后10~14 d血清β-h CG值、不孕类型和流产次数,以及不同移植周期、胚胎类型、不孕因素、受精方式间枯萎卵发生率的比较。结果枯萎卵组的双方年龄、BMI、不孕年限、不孕类型、流产次数和活产组有显著性差异;β-h CG在枯萎卵组胎芽组活产组(P=0.000);囊胚移植较卵裂期胚胎显著增加枯萎卵的发生率(11.6%vs 5.6%,P=0.000);3组间其他参数无统计学差异(P0.05);经多因素Logistic回归分析,女方年龄、β-h CG和囊胚移植是枯萎卵发生的危险因素。结论女方高龄、血清β-h CG下降和囊胚移植增加枯萎卵发生的风险,枯萎卵的发生可能和早期胚胎发育的基因印记错误有关。
[Abstract]:Objective to investigate the incidence and influencing factors of withered eggs in pregnant women with assisted reproductive technique (art). Methods 2378 cases of pregnancy in vitro fertilization and embryo transfer were retrospectively analyzed from January 2012 to December 2015 in the Reproductive Center of Southern Hospital of Southern Medical University. Including early embryo suspension and simultaneous single birth, in which embryo suspension was divided into embryonic bud group and withered egg group according to the presence of embryo buds. Basic information was compared among three groups: withered egg group, fetal bud group and live birth group, such as the age of the woman and the age of the male. Body mass index (BMI), number of basic antral follicles, ratio of basal follicle stimulating hormone (FSH) and FSH/b LH, age of infertility, dosage of gonadotropin (Gnn) and days of Gn, estradiol value of human chorionic gonadotropin (hCG) injection day, thickness of endometrium on the day of transplantation, and number of eggs obtained. The rate of excellent embryo transplantation, the serum 尾 -hCG value of 10 days and 14 days after transplantation, the type of infertility and the times of abortion, the different transfer cycles, the types of embryos, the factors of infertility, Results the BMIs, the years of infertility, the type of infertility, the age of both sides of the wilted egg group, There were significant differences in abortion frequency and live delivery group, 尾 -hCG in embryo bud group of withered egg group (P0. 000), blastocyst transfer significantly increased the incidence of withered egg compared with blastocyst embryo group (11. 6 vs 5. 6%), there was no significant difference in other parameters among the three groups (P0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05). The age of female, 尾 -hCG and blastocyst transplantation were the risk factors of wilt oocytes. Conclusion in old age, serum 尾 -hCG decrease and blastocyst transplantation increase the risk of wilting eggs, and the occurrence of withered eggs may be related to gene imprinting errors in early embryonic development.
【作者单位】：南方医科大学南方医院妇产科生殖中心;
【基金】：国家科技支撑计划项目(2013BAI12B01-7) 广东省自然科学基金(1414050001657)~~
【分类号】：R714.8

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