179例试管婴儿孕妇发生先兆流产的病例对照研究

发布时间：2018-04-02 03:11

本文选题：先兆流产　切入点：影响因素　出处：《安徽医科大学学报》2015年11期

【摘要】：目的分析试管婴儿的孕妇发生先兆流产的相关影响因素,为预防试管婴儿孕妇发生先兆流产提供科学依据。方法病例组选取因患先兆流产而住院的孕妇87例;对照组均来自于同期做试管婴儿且无先兆流产的孕妇,共92例,调查试管婴儿孕妇先兆流产的影响因素。应用Epi Data3.1数据库及SPSS 17.0软件进行数据录入及统计分析,分析方法主要包括秩和检验、χ2检验、单因素和多因素条件Logistic回归分析;并计算各影响因素与先兆流产的关联强度(OR值)及其95%CI。结果单因素分析结果表明:两组研究对象的职业、文化程度、身高、体重、体质指数差异无统计学意义(P0.05)。但年龄差异有统计学意义(P0.05),两组研究对象在不良妊娠史、既往疾病史、不孕类型、不孕年限方面差异无统计学意义(P0.05);而两组在移植时子宫内膜厚度、移植的胚胎数目、移植胚胎的周期类型、孕妇的焦虑评分显示有统计学意义。多因素条件Logistic回归分析结果显示,胚胎移植时子宫内膜的厚度、移植胚胎的周期类型、妊娠期心理压力是先兆流产发生的独立危险因素(OR=1.169、0.304、0.898,95%CI分别为1.005~1.361、0.135~0.683、0854~0.944)。结论移植时子宫内膜厚度、移植胚胎的周期类型、妊娠期心理压力可能是先兆流产发生的独立危险因素。
[Abstract]:Objective to analyze the influencing factors of threatened abortion in IVF pregnant women, and to provide scientific basis for prevention of threatened abortion. Methods 87 pregnant women hospitalized with threatened abortion were selected in the case group. The control group were all from 92 pregnant women who had no threatened abortion in the same period. The influencing factors of threatened abortion were investigated. The data input and statistical analysis were carried out by using Epi Data3.1 database and SPSS 17.0 software. The main methods of analysis included rank sum test, 蠂 2 test, univariate and multivariate conditional Logistic regression analysis, and calculated the relative strength OR value of each influencing factor and threatened abortion) and 95 CIs. Results the results of univariate analysis showed the occupation of the two groups of subjects. There was no significant difference in education level, height, weight, body mass index (BMI). But there was significant difference in age (P 0.05). The subjects of the two groups were in the history of bad pregnancy, the history of previous disease, the type of infertility. There was no significant difference in the length of infertility between the two groups (P 0.05), but the thickness of endometrium, the number of embryos transferred, and the period of embryo transfer were different between the two groups. The anxiety scores of pregnant women were statistically significant. Multivariate conditional Logistic regression analysis showed that the thickness of endometrium at the time of embryo transfer, the type of cycle of embryo transfer, Psychological stress during pregnancy was the independent risk factor of threatened abortion. The CI was 1.005U 1.361U 0.135U 0.683n08540.9440.Conclusion the thickness of endometrium, the period of embryo transfer and the psychological stress during pregnancy may be the independent risk factors for the occurrence of threatened abortion.
【作者单位】：安徽医科大学第一附属医院生殖医学中心;安徽医科大学公共卫生学院;
【基金】：国家重大科学研究计划(编号:2012CB944704)
【分类号】：R714.21

【参考文献】