高龄IVF患者应用黄体期促排卵方案与GnRH-a超短方案的助孕结局比较

发布时间：2018-04-03 06:03

本文选题：高龄　切入点：体外受精-胚胎移植　出处：《中国现代医学杂志》2017年26期

【摘要】：目的观察黄体期促排卵方案与Gn RH-a超短方案在行体外受精-胚胎移植(IVF-ET)助孕高龄患者中的应用,探讨黄体期促排卵方案的有效性及可行性。方法对114例高龄患者161个IVF-ET周期过程及结局进行回顾性分析,其中,Gn RH-a超短方案83例(A组)、黄体期促排卵方案31例(B组),比较两种方案的促排卵效果及妊娠结局。结果与A组相比,B组人绝经期促性腺激素用量较多、重组促卵泡激素用量较少、促性腺激素(Gn)用量较多、Gn费用较少及受精率较高,优质胚胎率较低,组间比较,差异有统计学意义(P0.05)。两组患者在年龄、不孕年限、体重指数、基础卵泡刺激素、基础黄体生成素、基础雌二醇、Gn天数、扳机日雌二醇水平、平均获卵数、2PN、可利用胚胎数、可移植胚胎率、临床妊娠率及早期流产率等方面比较,差异无统计学意义(P0.05)。结论对于高龄患者,黄体期促排卵方案与Gn RH-a超短方案相比,在Gn费用较少的情况下有较高的受精率,且两组在总获卵数、可利用胚胎率及妊娠结局等方面比较,差异无统计学意义(P0.05),提示黄体期促排卵方案可作为高龄IVF患者理想的治疗方案。
[Abstract]:Objective To observe the luteal phase of ovulation induction with Gn RH-a ultra short scheme of in vitro fertilization and embryo transfer (IVF-ET) application of progesterone in elder patients, to explore the effectiveness and feasibility of the luteal phase for ovulation induction. Methods 114 cases of elderly patients with 161 cycles of IVF-ET process and outcome were retrospectively analyzed. Among them, Gn RH-a laser for 83 cases (group A), luteal phase ovulation for 31 cases (group B), ending a comparison of two schemes of ovulation induction and pregnancy. Results compared with A group, B group, human menopausal gonadotropin dosage, less dosage of recombinant follicle stimulating hormone, gonadotropin-releasing hormone (Gn) dosage. Gn cost less and higher fertilization rate, good embryo rate is low, comparison between groups, the difference was statistically significant (P0.05). The two groups in age, infertility duration, body mass index, follicle stimulating hormone, luteinizing hormone based, basic estradiol, Gn days, on the trigger Estradiol levels, the average number of oocytes, 2PN, number of available embryos, embryo transplant rate, compared the clinical pregnancy rate and early abortion rate, the difference was not statistically significant (P0.05). Conclusion for elderly patients, luteal phase ovulation scheme compared with the Gn RH-a scheme in Gn short, under the condition of less cost have a higher fertilization rate, and the two groups in the total number of oocytes, comparable by embryo rate and pregnancy outcome, there was no statistically significant difference (P0.05), suggesting that the luteal phase of ovulation induction regimen can be used as the treatment of elderly patients with IVF ideal.

【作者单位】：山东中医药大学;山东中医药大学附属医院;
【基金】：国家自然科学基金(No:81373676;81674018)
【分类号】：R714.8

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