橘荔散结片联合GnRH-a治疗围绝经期子宫肌瘤合并异常子宫出血的研究

发布时间：2018-04-03 09:52

本文选题：橘荔散结片　切入点：GnRH-a　出处：《广州中医药大学》2017年硕士论文

【摘要】：目的:观察橘荔散结片联合GnRH-a治疗围绝经期子宫肌瘤合并异常子宫出血的临床疗效,为临床运用中西医结合方法治疗此类患者提供临床依据。方法:收集年龄在40-55岁,经临床明确诊断为子宫肌瘤合并异常子宫出血的女性患者共35例,按照随机化原则分为中西结合组20例和西药组15例。中西结合组给予橘荔散结片联合GnRH-a,西药组给予GnRH-a。GnRH-a于月经第1天皮下注射,每28天为1周期,橘荔散结片每次口服4片,每天3次。两组疗程均为6月。治疗前后分别记录两组患者中医症候及月经情况积分、子宫及肌瘤体积、子宫内膜厚度、血红蛋白量并进行统计分析。结果:1.本研究表明,治疗前中西结合组和西药组在年龄、籍贯、婚姻、病程、病情程度、中医证候积分及月经情况评分、子宫及肌瘤体积、子宫内膜厚度、血红蛋白量方面比较差别无统计学意义(P0.05),具有可比性。2.经"橘荔散结片联合GnRH-a"及"GnRH-a"干预后,对比治疗前,两组患者中医症候积分及月经情况评分均下降,子宫及肌瘤体积均缩小,子宫内膜厚度均变薄,血红蛋白量均升高,且中西医结合组的上述疗效优于西药组,差异具有统计学意义(P0.05)。3.中西结合组总有效率为100.00%,治愈率为20.00%,显效率为65.00%,有效率为15.00%;西药组总有效率为73.33%,治愈率为0.00%,显效率为53.33%,有效率为20.00%。中西结合组总有效率高于西药组26.67%,两组疗效对比差异比较具有统计学意义(P0.05),中西结合组疗效优于西药组。结论:橘荔散结片联合GnRH-a治疗围绝经期子宫肌瘤合并异常子宫出血临床疗效较可观,值得临床推广应用。
[Abstract]:Objective: to observe the clinical effect of tangli Sanjie tablet combined with GnRH-a in the treatment of peri-menopausal uterine leiomyoma with abnormal uterine bleeding, and to provide clinical basis for the clinical treatment of this kind of patients with integrated traditional Chinese and western medicine.Methods: a total of 35 female patients aged 40-55 years with uterine leiomyoma complicated with abnormal uterine bleeding were collected. According to the principle of randomization, they were divided into Chinese and western combination group (n = 20) and western medicine group (n = 15).The combination group was given tangeri Sanjie tablet combined with GnRH-a, the western medicine group was subcutaneously injected with GnRH-a.GnRH-a on the 1st day of menstruation for 1 cycle every 28 days, and 4 tablets were taken orally, 3 times a day.The course of treatment in both groups was 6 months.Before and after treatment, the scores of TCM symptoms and menstruation, the volume of uterus and myoma, the thickness of endometrium, the amount of hemoglobin were recorded and analyzed statistically.The result is 1: 1.This study shows that before treatment, the combination of Chinese and Western medicine and western medicine group in age, place of origin, marriage, course of disease, degree of illness, TCM syndromes score and menstrual score, uterine and myoma volume, endometrial thickness,There was no significant difference in hemoglobin content (P 0.05), which was comparable. 2.After the intervention of "tangerine Lisanjie tablet combined with GnRH-a" and "GnRH-a", the scores of TCM symptoms and menstruation of the two groups decreased, the volume of uterus and myoma decreased, the thickness of endometrium became thinner, and the content of hemoglobin increased.And the combination of traditional Chinese and Western medicine group than the western medicine group, the difference is statistically significant P 0.05. 3.The total effective rate of the combination group was 100.00000, the cure rate was 20.00, the effective rate was 65.00 and the effective rate was 15.00.The total effective rate of the western medicine group was 73.33 and the cure rate was 0.000.The effective rate was 53.33 and the effective rate was 20.00.The total effective rate of the combination group was higher than that of the western medicine group (26.67%), and the difference between the two groups was statistically significant (P 0.05). The curative effect of the Chinese and Western combination group was better than that of the western medicine group.Conclusion: the clinical effect of tangli Sanjie tablet combined with GnRH-a in the treatment of peri-menopausal uterine leiomyoma with abnormal uterine hemorrhage is considerable and worthy of clinical application.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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