孕妇血清中PLGF、β-HCG水平与子痫前期关系研究

发布时间：2018-04-03 14:55

本文选题：人胎盘生长因子　切入点：人绒毛膜促性腺激素　出处：《昆明医科大学》2014年硕士论文

【摘要】：[目的] 通过检测人胎盘生长因子(Placental growth factor, PLGF)及人绒毛膜促性腺激素(Beta Human Chorionic Gonadotropin,(3-HCG)在正常妊娠、轻度子痫前期、重度子痫前期孕妇静脉血中水平变化,探讨PLGF与β-HCG在子痫前期发生发展中的作用及二者在子痫前期中的相关性。 [方法] 采用双抗体夹心酶联免疫吸附法(enzyme linked immunosorbent assay, ELISA)和化学发光免疫分析法(chemiluminescence immunoassay, CLIA),分别检测28例正常妊娠组、24例轻度子痫前期组、23例重度子痫前期组孕妇静脉血中的PLGF和P-HCG的水平,所得数据用SPSS17.0(Statistic Package for Social Science)统计软件包处理。 [结果] 1.正常妊娠组、轻度子痫前期组、重度子痫前期组孕妇静脉血中PLGF水平分别为(91.61±30.73) pg/ml、(72.05±22.40) pg/ml、(43.71±16.41) pg/ml。孕妇静脉血中PLGF水平比较发现,轻度子痫前期组比正常妊娠组明显降低(p0.05),重度子痫前期组比轻度子痫前期组明显降低(p0.05),重度子痫前期组比正常妊娠组明显降低(p0.05)。 2.正常妊娠组、轻度子痫前期组、重度子痫前期组孕妇静脉血中P-HCG水平分别为(24467.79±9716.99) mIU/ml、(42310.33±13570.31) mIU/ml、(56505.52±17968.80) mIU/ml。孕妇静脉血中β-HCG水平比较发现,轻度子痫前期组比正常妊娠组明显升高(p0.05),重度子痫前期组比轻度子痫前期组明显升高(p0.05),重度子痫前期组比正常妊娠组明显升高(p0.05)。 3PLGF与β-HCG在子痫前期孕妇静脉血中的水平呈负相关关系(r=-0.502,p=0.0000.05) [结论] 1.子痫前期孕妇静脉血中PLGF的水平低于正常妊娠孕妇。轻、重度子痫前期组与正常妊娠组,重度子痫前期组与轻度子痫前期组,组间的PLGF水平差异均有统计学意义,说明PLGF水平在正常妊娠组最高,轻度子痫前期组次之,重度子痫前期组最低。推测PLGF可能参与了子痫前期的发生与发展,且其水平变化与病情程度相关,水平越低则病情越重。 2.子痫前期孕妇静脉血中β-HCG的水平高于正常妊娠孕妇。轻、重度子痫前期组与正常妊娠组,重度子痫前期组与轻度子痫前期组,组间的β-HCG水平差异均有统计学意义,说明β-HCG水平在正常妊娠组最低,轻度子痫前期组次之,重度子痫前期组最高。推测β-HCG可能参与了子痫前期的发生与发展,并且其水平变化与病情程度相关,水平越高则病情越重。 3PLGF与β-HCG在子痫前期孕妇静脉血中的水平呈负相关关系,推测二者相互作用,共同参与子痫前期的发生,可作为联合预测子痫前期的指标。
[Abstract]:[purpose]The changes of serum levels of human placental growth factor (PLGF) and human chorionic gonadotropin (hCG) in normal pregnancy, mild preeclampsia and severe preeclampsia were measured.To investigate the role of PLGF and 尾 -HCG in the development of preeclampsia and their correlation with preeclampsia.[methods]The data were processed by SPSS17.0(Statistic Package for Social Science software package.[results]1.In normal pregnancy group, mild preeclampsia group and severe preeclampsia group, the levels of PLGF in venous blood of pregnant women were 91.61 卤30.73) PG / ml 72.05 卤22.40) PG / ml 43.71 卤16.41 respectively.The levels of PLGF in the vein blood of pregnant women were significantly lower in the mild preeclampsia group than in the normal pregnancy group, in the severe preeclampsia group than in the mild preeclampsia group, and in the severe preeclampsia group than in the mild preeclampsia group, and in the severe preeclampsia group as compared with the normal pregnancy group.2.The levels of P-HCG in venous blood of normal pregnancy group, mild preeclampsia group and severe preeclampsia group were 42310.33 卤13570.31) MIUP / ml, respectively.The levels of 尾 -HCG in the venous blood of pregnant women were significantly higher in the mild preeclampsia group than in the normal pregnancy group, in the severe preeclampsia group than in the mild preeclampsia group, and in the severe preeclampsia group as compared with that in the mild preeclampsia group, and in the severe preeclampsia group as compared with the normal pregnancy group.There was a negative correlation between 3PLGF and 尾 -HCG in venous blood of preeclampsia pregnant women.[conclusion]1.The level of PLGF in venous blood of preeclampsia pregnant women was lower than that of normal pregnant women.There were significant differences in PLGF levels between mild and severe preeclampsia group and normal pregnancy group, severe preeclampsia group and mild preeclampsia group, indicating that PLGF level was the highest in normal pregnancy group, followed by mild preeclampsia group.The group of severe preeclampsia was the lowest.It is speculated that PLGF may be involved in the occurrence and development of preeclampsia, and its level is related to the severity of the disease, and the lower the level, the more serious the disease.2.The level of 尾-HCG in venous blood of preeclampsia pregnant women was higher than that of normal pregnant women.There were significant differences in 尾 -HCG levels between mild and severe preeclampsia group and normal pregnancy group, severe preeclampsia group and mild preeclampsia group, indicating that 尾 -HCG level was the lowest in normal pregnancy group, followed by mild preeclampsia group.Severe preeclampsia group was the highest.It is speculated that 尾 -HCG may be involved in the occurrence and development of preeclampsia, and the level of 尾 -HCG may be related to the severity of the disease, and the higher the level, the more serious the disease.There was a negative correlation between 3PLGF and 尾 -HCG levels in the venous blood of preeclampsia pregnant women. It was speculated that both of them interact with each other and participate in the occurrence of preeclampsia, which can be used as a combined predictor of preeclampsia.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.244

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