不同剂量来曲唑预防早发型卵巢过度刺激综合征的临床研究

发布时间：2018-04-04 07:04

本文选题：卵巢过度刺激综合征(OHSS)　切入点：体外受精(IVF)　出处：《生殖与避孕》2016年09期

【摘要】：目的:探讨卵巢过度刺激综合征(OHSS)高危患者在取卵后应用不同剂量来曲唑(LE)预防早发型OHSS发生的效果。方法:88例患者随机分为4组,A~C组为LE组,取卵即日起每日添加LE,LE剂量分别为A组(n=21)2.5 mg/d,B组(n=23)5.0 mg/d,C组(n=20)7.5 mg/d,D组为对照组(n=24)。测患者黄体期内分泌、血管内皮细胞生长因子(VEGF)水平及中重度OHSS发生率。结果:h CG注射后第5日始血清E_2水平随时间变化呈降低趋势,随着LE剂量增加,E_2水平降低速度明显加快,组间差异有统计学意义(P0.05)。血清LH水平在注射h CG后第8日、第10日随着LE剂量的增加而逐渐上升,P水平却逐渐降低,组间差异显著(P0.05)。血清VEGF水平从h CG注射后5日始,D组呈上升趋势,而其它三组呈下降趋势,随着LE剂量的增加,血中VEGF水平越低,各组之间两两比较,差异均具有统计学意义(P0.001)。C组中重度OHSS发生率低于D组。结论:不同剂量的LE均能一定程度降低血清E_2及VEGF水平,当剂量增至7.5 mg/d时,OHSS发生率最低。
[Abstract]:Objective: to investigate the effect of different doses of letrozole on the prevention of early onset OHSS in high risk patients with ovarian hyperstimulation syndrome (OHSS).In luteal phase, the level of vascular endothelial growth factor (VEGF) and the incidence of moderate and severe OHSS were measured.Results the serum E2 level decreased with time from the 5th day after the injection of w hCG, and increased with the increase of le dose. The decrease rate of serum E _ 2 level was significantly increased with the increase of le dose, and the difference between groups was statistically significant (P _ (0.05)).The serum LH level increased gradually with the increase of le dose on the 8th and 10th day after hCG injection, and the difference between groups was significant (P 0.05).The serum VEGF level increased from 5 days after hCG injection, but decreased in the other three groups. With the increase of le dose, the level of VEGF in blood was lower.The incidence of moderate and severe OHSS in group C was lower than that in group D.Conclusion: the serum E2 and VEGF levels can be decreased to a certain extent with different doses of le, and the incidence of OHSS is the lowest when the dose increases to 7.5 mg/d.
【作者单位】：河南省人民医院郑州大学人民医院;
【基金】：河南省科技厅重点科技攻关项目(132106000081)
【分类号】：R714.8

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