HCG联合GnRH-a在微刺激方案体外受精治疗中的应用

发布时间：2018-04-04 08:49

本文选题：不孕症　切入点：体外受精　出处：《山东医药》2015年34期

【摘要】：目的探讨绒毛膜促性腺激素(HCG)联合促性腺激素释放激素激动剂(GnRH-a)在微刺激方案体外受精(IVF)患者诱导卵泡成熟中的应用效果。方法选择使用微刺激方案行IVF的患者40例,其中使用HCG联合GnRH-a治疗20例(联合组)、HCG治疗20例(单药组)。比较两组的促性腺激素(Gn)天数、Gn用量、HCG日雌二醇(E2),HCG日后第1天E2、孕酮(P)、HCG,获卵数、成熟卵数、受精率、移植胚胎数、临床妊娠率。结果联合组与单药组的Gn天数、Gn用量、HCG日E2水平比较,P均0.05。与单药组比较,联合组HCG日后第1天E2水平降低、P及HCG升高、获卵数及成熟卵数增加(P均0.05)。两组受精率、移植胚胎数及临床妊娠率比较,P均0.05。结论 HCG联合GnRH-a用于微刺激方案IVF可以增加获卵数和成熟卵数。
[Abstract]:Objective to investigate the effect of HCG combined with gonadotropin releasing hormone agonist (GnRH-a) on follicular maturation induced by microstimulation in vitro fertilization (IVF).Methods A total of 40 patients with IVF were treated with microstimulation regimen, 20 of them were treated with HCG combined with GnRH-a.Results the levels of E _ 2 on HCG and Gn dosage in combination group and single drug group were 0. 05 and 0. 05 respectively.Compared with the single drug group, the E2 level of the combined group decreased on the 1st day after HCG, the level of P and HCG increased, the number of acquired eggs and the number of mature eggs increased (P 0.05).The fertilization rate, the number of embryos transferred and the clinical pregnancy rate of the two groups were 0.05.Conclusion HCG combined with GnRH-a can increase the number of eggs acquired and matured by IVF.
【作者单位】：唐山市妇幼保健院;
【分类号】：R714.8

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