消积冲剂治疗湿热瘀阻型子宫内膜异位症的临床研究及对血清VEGF的影响

发布时间：2018-04-05 13:51

本文选题：子宫内膜异位症　切入点：湿热瘀阻　出处：《南京中医药大学》2014年硕士论文

【摘要】：目的：观察消积冲剂治疗湿热瘀阻型子宫内膜异位症的临床疗效,并检测外周血CA125、EMMAb及血清VEGF的变化,探讨消积冲剂治疗子宫内膜异位症的作用机理。方法：将本研究符合湿热瘀阻型子宫内膜异位症的56例患者,随机分为两组：治疗组30例,口服消积冲剂；对照组26例,口服散结镇痛胶囊。观察治疗前后患者的症状及体征的改善情况,检测治疗前后患者的血清CA125、EMAb及VEGF的变化情况。结果：治疗组30例,总有效率80%；对照组26例,总有效率76.9%。治疗组与对照组比较差异无统计学意义(P0.05)。两组治疗后患者的痛经、非经期盆腔痛疼痛程度降低,性交痛阳性率下降,组内比较均有统计学意义(P0.05)。两组治疗后患者的囊肿缩小,组内比较有统计学意义(P0.05)。两组治疗后患者的血清CA125下降,组内比较有统计学意义(P0.05),治疗前后组间比较无统计学意义(P0.05)。两组治疗后患者的血清VEGF下降,组内比较有统计学意义(P0.05),治疗前后组间比较无统计学意义(P0.05)。两组治疗前后患者的血清EMAb组内比较有统计学意义(P0.05)。结论：消积冲剂是治疗子宫内膜异位症的安全、有效的药物,它可以明显缓解患者的症状及体征,降低血清CA125,促使EMAb转阴,调节患者的免疫功能,降低血清VEGF,减少异位病灶形成。
[Abstract]:Objective: to observe the clinical effect of Xiaoji granule in treating endometriosis of damp-heat stasis type, and to detect the changes of serum VEGF and CA125 VEGF, and to explore the mechanism of Xiaoji granule in treating endometriosis.Methods: 56 patients with endometriosis of damp-heat stasis type were randomly divided into two groups: treatment group (n = 30) and control group (n = 26).To observe the improvement of symptoms and signs before and after treatment, and to detect the changes of serum CA125 Emab and VEGF before and after treatment.Results: the total effective rate was 80% in the treatment group (30 cases) and 76. 9% in the control group (26 cases).There was no significant difference between the treatment group and the control group (P 0.05).After treatment, the degree of dysmenorrhea, non-menstrual pelvic pain and the positive rate of coitus pain were decreased in the two groups, and there was significant difference between the two groups (P 0.05).The cysts of the two groups were reduced after treatment, and there was significant difference between the two groups (P 0.05).The serum CA125 of the two groups decreased after treatment, there was significant difference between the two groups (P 0.05), but there was no significant difference between the two groups before and after treatment (P 0.05).The serum VEGF of the two groups decreased after treatment, there was significant difference between the two groups (P 0.05), but there was no significant difference between the two groups before and after treatment (P 0.05).There was significant difference in serum EMAb between the two groups before and after treatment (P 0.05).Conclusion: Xiaoji granule is a safe and effective drug for the treatment of endometriosis. It can obviously relieve the symptoms and signs of the patients, reduce the serum CA125, promote the conversion of EMAb to negative, and regulate the immune function of the patients.Reduce serum VEGF and ectopic lesion formation.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.71

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