非优良胚胎形成的囊胚与卵裂期优良胚胎的冻融胚胎移植的临床结局比较

发布时间：2018-04-06 06:16

本文选题：囊胚移植　切入点：玻璃化冷冻　出处：《南方医科大学学报》2015年04期

【摘要】：目的探讨不同发育天数胚胎的发育潜能,为D3非优良胚胎进行囊胚培养及其冻融移植提供依据。方法回顾性分析687例复苏周期胚胎移植患者的资料,根据胚胎冷冻时间不同,分为3组:D5冷冻组(n=87)、D6冷冻组(n=111)和D3冷冻组(n=489),采用外源性雌孕激素或自然周期准备内膜,比较各组间的临床妊娠率、流产率、种植率等指标。结果每组移植周期临床妊娠率、流产率、种植率分别为:D5冷冻组58.6%、9.8%、42.9%;D6冷冻组32.4%、19.4%、23.3%;D3冷冻组44.9%、16.4%、26.9%。D5冷冻组的临床妊娠率和种植率均明显高于另外两组,且差异均具有统计学意义(P0.05)。结论 D3的非优良胚胎继续培养,若能够形成囊胚,所形成的D5囊胚冻融移植的临床结局优于D3的优良胚胎和非优良胚胎形成的D6囊胚冻融移植的临床结局。因此D3的非优良胚胎的囊胚培养及其冻融移植具有临床应用价值,且在冻融胚胎移植周期若有不同冷冻时间的胚胎可供选择时,可以优先选择非优良胚胎来源的D5囊胚,其次选择D3的卵裂期胚胎。
[Abstract]:Objective to explore the developmental potential of embryos with different development days, and to provide evidence for blastocyst culture and freeze-thaw transfer of D 3 non-fine embryos.Methods 687 cases of embryo transfer in the resuscitation cycle were retrospectively analyzed. According to the different freezing time of embryos, they were divided into 3 groups: 1% D5 cryopreservation group and 489% D3 cryopreservation group. The endometrium was prepared with exogenous estrogen or natural cycle.The clinical pregnancy rate, abortion rate and implantation rate were compared among the groups.Conclusion the freeze-thaw transfer of D5 blastocyst is better than that of D3 and D6 blastocysts if the embryos of D3 continue to be cultured and blastocysts can form blastocysts.Therefore, the blastocyst culture and freeze-thawing transfer of non-fine embryos of D3 have clinical application value, and D5 blastocysts from non-fine embryos can be selected in preference if there are embryos with different freezing time available in the frozen and thawed embryo transfer cycle.Secondly, the cleavage embryo of D 3 was selected.
【作者单位】：南方医科大学南方医院妇产科生殖医学中心;
【基金】：国家自然科学基金(31371517,81170574) 广州市科技计划项目重点项目(2011J4100001) 南方医院高层次课题匹配经费(G201206)~~
【分类号】：R714.8

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