米氮平治疗伴有睡眠障碍围绝经期综合征的临床观察

发布时间：2018-04-09 03:01

本文选题：围绝经期综合征　切入点：米氮平　出处：《中国药房》2015年33期

【摘要】：目的:观察米氮平治疗伴有睡眠障碍围绝经期综合征的疗效和安全性。方法:100例围绝经期患者随机分为研究组(52例)和对照组(48例)。研究组患者给予米氮平片起始剂量15 mg,睡前1~2 h服用,每日1次,1周后增加剂量并维持至30 mg;对照组患者给予谷维素片10 mg,饭后服用,每日3次。两组患者疗程均为8周。观察两组患者治疗前后汉密尔顿抑郁量表17项(HAMD-17)评分、匹兹堡睡眠质量指数(PSQI)评分,并据此评价睡眠疗效和抑郁疗效,观察2组的不良反应发生情况。结果:治疗后,研究组患者HAMD-17评分、PSQI评分均显著低于同组治疗前及对照组,且8周末4周末2周末,差异均有统计学意义(P0.05或P0.01)。研究组患者抑郁、睡眠总有效率显著高于对照组,差异均有统计学意义(P0.05)。但研究组患者不良反应发生率显著高于对照组,差异有统计学意义(P0.05)。结论:米氮平治疗改善围绝经期综合征的抑郁焦虑症状疗效显著,可改善睡眠,起效快速,但不良反应有待进一步观察。
[Abstract]:Objective: to observe the efficacy and safety of mirtazapine in the treatment of peri-menopausal syndrome with sleep disorder.Methods 100 cases of perimenopausal patients were randomly divided into study group (n = 52) and control group (n = 48).The patients in the study group were given metozapine at the initial dose of 15 mg at 1h before bedtime, the dose was increased once a week and maintained to 30 mg, while the patients in the control group were given 10 mg oryzanol tablets three times a day after meals.The course of treatment was 8 weeks.Before and after treatment, 17 items of Hamilton Depression scale (Hamd-17) and Pittsburgh Sleep quality Index (PSQI) were evaluated.Results: after treatment, the HAMD-17 scores of the patients in the study group were significantly lower than those in the same group and the control group before treatment, and the differences were statistically significant (P0.05 or P0.01) at the end of the 8th weekend and the 4th weekend and the 2nd weekend.The total effective rate of depression and sleep in the study group was significantly higher than that in the control group (P 0.05).However, the incidence of adverse reactions in the study group was significantly higher than that in the control group (P 0.05).Conclusion: mirtazapine is effective in improving depression and anxiety symptoms of perimenopausal syndrome. It can improve sleep and take effect quickly, but the adverse reactions need to be further observed.
【作者单位】：宁波市第二医院神经内科;
【分类号】：R711.75;R740

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