基因重组卵泡刺激素和高纯度尿促卵泡素对体外受精-胚胎移植中的治疗结局的影响

发布时间：2018-04-09 13:24

本文选题：基因重组FSH(r-FSH)　切入点：高纯度尿源性FSH(HP-uFSH)　出处：《中国妇产科临床杂志》2015年03期

【摘要】：目的比较基因重组卵泡刺激素(rFSH)和高纯度尿促卵泡素(HP-uFSH)对体外受精-胚胎移植治疗过程及妊娠结局的影响。方法回顾性分析北京大学第三医院生殖医学中心自2012年1月至2013年6月行体外受精-胚胎移植(IVF-ET)治疗采用长方案的患者共5 608例,并将其按促性腺激素(Gn)启动日用药的不同分为rFSH与HP-uFSH组,比较两组之间在用药时间、用药量、人绒毛膜促性腺激素(hCG)注射日激素水平、获卵数、胚胎情况、妊娠结局及中重度卵巢过度刺激综合征(OHSS)发生率及活产率方面的差异。结果HP-uFSH组Gn用量及用药天数高于rFSH组,hCG注射日雌激素及黄体酮水平明显低于rFSH组,获卵数目、可移植胚胎数、优质胚胎数明显少于rFSH组,差异均具有统计学意义(P0.05);而在种植率、临床妊娠率、宫外孕发生率、流产率、活产率、中重度卵巢过度刺激综合征(OHSS)发生率方面,两组之间不存在统计学差异(P0.05)。结论在IVF治疗中,应用HP-uFSH促排卵作用相对较温和,但具有与rFSH等同的临床妊娠率及活产率。
[Abstract]:Objective to compare the effects of recombinant follicle stimulating hormone (rFSH) and high purity urinary follicle stimulating hormone (HP-uFSH) on in vitro fertilization and embryo transfer (IVF) and pregnancy outcome.Methods from January 2012 to June 2013, the Center of Reproductive Medicine, third Hospital of Peking University, received IVF-ETS in vitro fertilization and embryo transfer for 5,608 patients.They were divided into rFSH group and HP-uFSH group according to the day of gonadotropin (Gnn) priming. The levels of hormone, the number of eggs and the embryo were compared between the two groups on the day of administration, dose of drug and human chorionic gonadotropin (hCGG).The difference of pregnancy outcome and OHSS rate of moderate and severe ovarian hyperstimulation syndrome.Results the levels of estrogen and progesterone in HP-uFSH group were significantly lower than those in rFSH group. The number of eggs obtained, the number of embryos transferable and the number of high-quality embryos in HP-uFSH group were significantly lower than those in rFSH group, and the difference was statistically significant (P 0.05).There was no significant difference in clinical pregnancy rate, ectopic pregnancy rate, abortion rate, live delivery rate and incidence of moderate and severe ovarian hyperstimulation syndrome (OHSS) between the two groups (P 0.05).Conclusion in the treatment of IVF, the effect of HP-uFSH on ovulation is relatively mild, but it has the same clinical pregnancy rate and live delivery rate as rFSH.
【作者单位】：北京大学第三医院生殖医学中心;
【分类号】：R714.8

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