唐氏综合征无创产前筛查策略的经济学系统评价

发布时间：2018-04-09 17:22

本文选题：唐氏综合征　切入点：无创产前检测技术　出处：《中国卫生资源》2017年02期

【摘要】：目的:系统评价唐氏综合征无创产前检测技术(NIPT)的经济性。方法:检索与唐氏综合征NIPT经济学评价相关的文献,对纳入文章进行质量评价,运用描述性方法系统评价筛查策略的经济性。结果:根据纳入和排除的标准,两名评价人员独立评价文献质量后,共纳入15篇文献,文献质量得分在18分以上的占46.7%。其中有10项研究涉及将NIPT作为二次深度筛查提供给孕妇,12项研究涉及将NIPT提供给所有孕妇,3项研究涉及将NIPT提供给35岁孕妇的筛查策略,1项研究涉及将NIPT作为产前诊断手段。目前将NIPT作为二次深度筛查提供给孕妇被认为是成本效果更好的策略。结论:NIPT是十分有应用前景的一种新技术,目前不推荐所有孕妇使用NIPT,如果其与当前的孕母血清学筛查更好地结合使用,作为条件筛查策略则经济性更好。随着未来价格的降低,它的经济性将会更为显著。
[Abstract]:Objective: to evaluate the economy of non-invasive prenatal detection technique for Down's syndrome (NIPT).Methods: literature related to the economic evaluation of Down's syndrome (NIPT) was searched, the quality of the included articles was evaluated, and the economy of screening strategy was systematically evaluated by descriptive method.Results: according to the criteria of inclusion and exclusion, 15 articles were included after two evaluators independently evaluated the quality of the literature, and 46.7% of them had a score of more than 18 points.Ten of these studies involved providing NIPT as a secondary screening for pregnant women. 12 studies involved making NIPT available to all pregnant women. Three studies involved screening strategies for NIPT in 35-year-olds. One study involved NIPT as a means of prenatal diagnosis.Providing NIPT as a secondary screening for pregnant women is now considered a more cost-effective strategy.Conclusion: NIPT is a promising new technique. It is not recommended for all pregnant women to use NIPT at present. If it is better combined with current maternal serological screening, it will be more economical as a conditional screening strategy.With the future price reduction, its economy will be more significant.
【作者单位】：复旦大学公共卫生学院/卫生计生委卫生技术评估重点实验室/国民健康社会风险预警协同创新中心;加拿大劳伦森大学乡镇和北部卫生服务研究所;
【基金】：2015年国家卫生计生委卫生技术评估项目资助美国中华医学基金会卫生技术评估合作项目资助(13-153)
【分类号】：R714.5

【参考文献】