青海汉、藏、回族女性宫颈癌中Merlin蛋白的表达意义

发布时间：2018-04-11 00:07

本文选题：子宫颈鳞癌 + Merlin蛋白　；参考：《实用医学杂志》2017年11期

【摘要】：目的:探讨Merlin蛋白在青海汉、藏、回族女性正常宫颈与宫颈癌中的表达意义。方法:采用免疫组化法对青海108例宫颈癌(汉族40例、藏族38例、回族30例)及107例正常宫颈(汉族40例、藏族37例、回族30例)中Merlin表达进行检测。结果:(1)40例汉、37例藏、30例回族正常宫颈中Merlin阳性表达率为90.0%、91.9%、86.7%;Merlin在40例汉、38例藏、30例回族宫颈癌中阳性表达率为17.5%、18.4%、16.7%,差异有统计学意义(P0.05);各民族间宫颈癌Merlin阳性表达率无差异(P0.05);(2)三民族间宫颈癌Merlin表达均与患者年龄、FIGO分期、淋巴转移及细胞分化无关(P0.05)。结论:(1)青海各民族女性宫颈癌Merlin蛋白表达下降、缺失促进了宫颈癌的发生,Merlin在宫颈癌中发挥抑癌功能;(2)Merlin表达不影响民族间宫颈癌的发生;(3)Merlin表达与患者临床特征无关,提示其可能未直接参与宫颈癌的浸润、转移过程。
[Abstract]:Objective: to investigate the expression of Merlin protein in normal cervix and cervical cancer of Han, Tibetan and Hui women in Qinghai.Methods: the expression of Merlin in 108 cases of cervical cancer (40 Han, 38 Tibetans, 30 Hui) and 107 normal cervix (40 Han, 37 Tibetan and 30 Hui) were detected by immunohistochemical method.The expression of Merlin in cervical cancer was correlated with age and Figo stage.Lymphatic metastasis and cell differentiation were not associated with P0.05.Conclusion (1) the expression of Merlin protein in cervical cancer of all ethnic groups in Qinghai decreased, and the absence of Merlin promoted the occurrence of cervical cancer. The expression of Merlin in cervical cancer did not affect the occurrence of cervical cancer among different ethnic groups. There was no correlation between the expression of Merlin and the clinical characteristics of cervical cancer.It may not be directly involved in the process of invasion and metastasis of cervical cancer.
【作者单位】：青海红十字医院妇产科;青海红十字医院血液科;
【基金】：青海省自然科学基金项目(编号:2014-ZJ-912)
【分类号】：R737.33

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