稀释式自体输血对宫颈癌术后血栓形成的影响

发布时间：2018-04-14 08:48

本文选题：稀释式自体输血 + 宫颈癌　；参考：《实用妇产科杂志》2015年09期

【摘要】：目的:评价稀释式自体输血对宫颈癌术后血栓形成的影响。方法:因宫颈癌ⅠB1行宫颈癌根治术的患者80例,随机分成观察组、对照组,每组40例。观察组患者术前采用稀释式自体输血,对照组患者按常规手术。分别于入室开放静脉后(T0)、术毕(T1)、术后24小时(T2)抽取两组肘静脉血样,检测血红蛋白(Hb)、血细胞比容(HCT)、凝血功能指标及血液流变学变化指标。用彩色多普勒超声于术前1天及术后7天探测两组患者双下肢深静脉通畅情况。结果:与T0比较,T1及T2时观察组患者Hb和HCT明显降低,与对照组同一时点比较差异有统计学意义(P0.05)。与T0比较,T1及T2时观察组全血黏度高切变率、全血黏度低切变率、血浆黏度及红细胞聚集指数降低,红细胞变形指数升高;对照组T1及T2时血浆黏度降低且T2时D-二聚体升高(P0.05)。与对照组比较,观察组T1及T2时全血黏度高切变率、全血黏度低切变率及红细胞聚集指数降低,红细胞变形指数升高,T2时观察组D-二聚体降低(P0.05)。术后7天时,彩色多普勒超声下,对照组DVT发生率12.5%,观察组无DVT发生。观察组DVT发生率低于对照组(P0.05)。结论:稀释式自体输血能改善手术患者血液流变学状态,降低发生深静脉血栓形成的危险。
[Abstract]:Objective: to evaluate the effect of dilute autologous blood transfusion on postoperative thrombosis of cervical cancer.Methods: 80 patients with cervical cancer undergoing radical cervical cancer resection were randomly divided into observation group (n = 40) and control group (n = 40).The patients in the observation group were treated with dilute autologous blood transfusion before operation, while the patients in the control group were treated by routine operation.The blood samples of cubitus vein were collected after operation and 24 hours after operation. Hemoglobin, HCT, coagulation function and hemorheology were measured.The patency of deep veins of both lower extremities was detected by color Doppler ultrasound 1 day before operation and 7 days after operation.Results: compared with T0, HB and HCT in the observation group were significantly lower than those in the control group at T _ 1 and T _ 2, and there was a significant difference between the two groups at the same time point (P 0.05).Compared with T0, the observed group had high shear rate of whole blood viscosity, low shear rate of whole blood viscosity, decreased plasma viscosity and erythrocyte aggregation index, and increased erythrocyte deformability index, while in control group, plasma viscosity decreased at T1 and T2 and D-dimer increased at T2 (P 0.05).Compared with the control group, the observation group had high shear rate of whole blood viscosity at T1 and T2, low shear rate of whole blood viscosity and erythrocyte aggregation index.On the 7th day after operation, the incidence of DVT in the control group was 12.5, and no DVT occurred in the observation group.The incidence of DVT in the observation group was lower than that in the control group (P 0.05).Conclusion: diluted autologous blood transfusion can improve hemorheology and reduce the risk of deep venous thrombosis.
【作者单位】：浙江省嘉兴市妇幼保健院;
【分类号】：R737.33

【参考文献】