宫颈癌术后调强放疗与常规4野计划剂量学比较及放射反应分析

发布时间：2018-04-15 23:01

本文选题：宫颈癌术后 + 调强放疗　；参考：《南京医科大学学报(自然科学版)》2015年05期

【摘要】：目的 :研究宫颈癌术后7野调强放疗计划与常规4野放疗计划(4野箱式照射)对危及器官的保护,并分析比较两种计划所产生的急性放射反应。方法:选取本院50例患者,其中25例为已行调强放疗,确定为调强组;另25例为已行常规放疗,确定为常规组。调强组同时设计常规4野模拟计划,与调强计划进行比较,做剂量学研究;同时,调强组与常规组进行急性反应的比较研究。结果:调强计划中达到46 Gy剂量包含临床靶区(CTV)体积显著常规4野计划(P0.05)。调强计划46 Gy包绕小肠、直肠、膀胱及骨髓的体积显著4野计划(P0.05)。调强组的1、2级恶心呕吐(P=0.002)、腹泻(P=0.048)、白细胞下降(P=0.02)、血红蛋白下降(P=0.005)明显少于4野常规组。结论 :调强计划较常规计划对保护危及器官具有明显剂量学优势,可以明显减少急性放射损伤。
[Abstract]:Objective: to study the protective effects of 7 field intensity-modulated radiotherapy (IMRT) plan on cervical cancer and 4 field box radiotherapy plan on cervical cancer, and to compare the acute radiation response between the two plans.Methods: 50 patients in our hospital were selected, 25 of them were treated with intensity modulated radiotherapy (IMRT) and 25 were treated with conventional radiotherapy.The intensity modulated group also designed the conventional 4 field simulation plan, compared with the intensity control plan, and did the dosimetry study, meanwhile, the intensity modulated group and the conventional group carried on the acute reaction comparison research.Results: the volume of CTV with 46 Gy dose in the intensity modulated program was significantly higher than that in the conventional 4-field plan (P 0.05).The volume of the small intestine, rectum, bladder and bone marrow around the 46 Gy intensity modulated program was significantly 4 field planning (P0.05A).In the intensity control group, the levels of P0. 002, P0. 048, P0. 02, P0. 005) of grade 1 and 2 nausea and vomiting were significantly less than those of the 4 field routine group (P < 0. 002, P < 0. 005).Conclusion: the intensity modulation plan has obvious dosimetric advantage in protecting the endangered organs compared with the conventional plan, and can obviously reduce the acute radiation injury.
【作者单位】：南京医科大学附属淮安第一医院放疗科;
【分类号】：R737.33

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