宫颈癌筛查中HPV检测初筛的分流检测

发布时间：2018-04-16 09:09

本文选题：宫颈癌筛查 + HPV检测　；参考：《实用妇产科杂志》2016年08期

【摘要】：宫颈癌是常见的恶性肿瘤,只有进行有效的筛查才能做到早发现、早诊治,降低宫颈癌的发病率与死亡率。目前国内外宫颈癌筛查方案多样,但均有不同的局限性。随着高危型人乳头瘤病毒(HR-HPV)与宫颈癌及癌前病变关系的深入研究,HPV检测也成为宫颈癌筛查中重要的部分。HPV检测初筛对于宫颈癌及癌前病变的检出具有较高的敏感性,但特异性较低。国内外研究者不断探索新式检测方法对HPV阳性者进行分流检测,以提高宫颈癌筛查的效力。目前国内外有关HPV阳性者分流检测的方法包括细胞学检测分流、HPV分型检测分流、HPV mRNA检测分流、分子标志物分流等。各种检测方法均有利弊,一些检测相关标志物的研究仍处于起步阶段,需大宗设计严谨的临床试验进行验证。
[Abstract]:Cervical cancer is a common malignant tumor. Only through effective screening can early detection, early diagnosis and treatment reduce the incidence and mortality of cervical cancer.At present, there are various screening programs for cervical cancer at home and abroad, but they all have different limitations.With the in-depth study of the relationship between high risk human papillomavirus (HR-HPV) and cervical cancer and precancerous lesions, HPV detection has become an important part of cervical cancer screening. HPV screening is highly sensitive to the detection of cervical cancer and precancerous lesions.But the specificity was low.In order to improve the effectiveness of cervical cancer screening, researchers at home and abroad have been exploring new detection methods to detect HPV positive patients by shunt.At present, the methods of shunt detection for HPV positive patients at home and abroad include cytological detection, HPV typing, shunt, molecular marker shunt, and so on.There are advantages and disadvantages of various detection methods, and the research of some related markers is still in its infancy, which needs to be verified by a large number of well-designed clinical trials.
【作者单位】：北京大学第三医院;
【分类号】：R737.33

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