卵巢恶性Wolffian肿瘤临床病理观察

发布时间：2018-04-16 10:21

  本文选题：Wolffian肿瘤 + 病理学诊断　； 参考：《临床与实验病理学杂志》2017年03期

【摘要】：目的 探讨卵巢恶性Wolffian肿瘤的临床病理学特征、诊断及鉴别诊断。方法 对1例卵巢恶性Wolffian肿瘤进行HE及免疫组化Max Vision法染色,并进行临床病理观察。结果 患者临床表现为绝经后阴道流血,术中可见左侧卵巢囊实性肿瘤,镜下肿瘤细胞呈立方形或短梭形,形态温和,呈管状、腺泡状、裂隙状或束状排列,核分裂象易见(35/10 HPF)。免疫组化示肿瘤细胞CK、vimentin、CD10、Pax-8均呈阳性,EMA、CD117均呈灶阳性,Calretinin、α-inhibin、CD99、ER、PR、CK7、CK20、CD56、Napsin A均呈阴性,p53阳性率约3%,Ki-67增殖指数约30%。结论 卵巢恶性Wolffian肿瘤临床罕见,核分裂活跃及高增殖指数可能是诊断恶性Wolffian肿瘤的重要指标。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of malignant ovarian Wolffian tumors.Methods A case of malignant ovarian Wolffian tumor was studied by HE and Max Vision immunohistochemical staining.Results the clinical manifestations of the patients were postmenopausal vaginal bleeding. The left ovarian cystic solid tumor was seen during the operation. Under microscope, the tumor cells were square or short fusiform, mild in shape, tubular, acinar, fissure or bundles, and mitosis was easy to be seen in 35% 10 HPFs.Immunohistochemistry showed that all the tumor cells were positive for pax-8 and EMA-CD117 were focal positive for Calretinin, and 伪 -inhibinus CD99ERT / PRCK7CK20 / CD56 / Napsin A were all negative for p53. The Ki-67 proliferative index was about 30%.Conclusion malignant ovarian Wolffian tumors are rare in clinic. Mitotic activity and high proliferative index may be important markers in the diagnosis of malignant Wolffian tumors.
【作者单位】： 广西壮族自治区人民医院病理科;
【分类号】：R737.3
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本文编号：1758479