血清造血生长因子在宫颈癌早期诊断中的价值

发布时间：2018-04-16 14:00

本文选题：宫颈癌 + 宫颈上皮内瘤变　；参考：《广东医学》2017年19期

【摘要】：目的检测宫颈癌及癌前病变患者血清中造血生长因子(HGFs)的表达水平,评估HGFs在宫颈癌早期诊断中的应用价值。方法选择宫颈癌患者49例、宫颈上皮内瘤变(CIN)患者60例、健康体检者40例为研究对象,采取血清标本,酶联免疫法检测HGFs表达水平[包括干细胞因子(SCF)、粒细胞巨噬细胞刺激因子(GMCSF)、粒细胞集落刺激因子(G-CSF)和巨噬细胞集落刺激因子(M-CSF)],化学发光微粒免疫分析法检测宫颈癌肿瘤标记物鳞状细胞癌抗原(SCC-Ag)表达,对检测结果进行对比分析。结果 GM-CSF、G-CSF和M-CSF在宫颈癌及CIN患者中表达水平显著高于健康体检者(P0.05),GM-CSF和M-CSF在宫颈癌患者的表达水平显著高于CIN患者(P0.05),SCC-Ag在宫颈癌患者的表达水平显著高于CIN患者和健康体检者(P0.05)。M-CSF、GM-CSF、G-CSF、SCC-Ag诊断宫颈癌的特异度均较高,其中M-CSF诊断的敏感度、阳性预测值和阴性预测值均高于SCC-Ag,M-CSF与SCC-Ag组合后诊断水平高于单独应用SCC-Ag。结论对HGFs的深入研究可能为寻找新的宫颈癌肿瘤标记物开辟新的途径,尤其是M-CSF具有作为一个良好的宫颈癌和CIN标记物的潜能,可作为早期诊断宫颈癌及CIN的可能因子。
[Abstract]:Objective to detect cervical cancer and precancerous lesions in patients with hematopoietic growth factor (HGFs) expression levels, assess the application value of HGFs in diagnosis of early cervical carcinoma. Methods 49 cases of patients with cervical cancer, cervical intraepithelial neoplasia (CIN) patients with 60 cases, 40 cases of healthy people were taken as the research object. Serum samples were detected by enzyme linked immunosorbent assay, HGFs expression levels including stem cell factor (SCF), granulocyte macrophage colony stimulating factor (GMCSF), granulocyte colony stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF), chemiluminescence analysis method to detect cervical cancer tumor markers of squamous cell carcinoma antigen particles immune (SCC-Ag) expression, the comparative analysis of the test results. The results of GM-CSF, G-CSF and M-CSF expression in cervical cancer patients and the CIN level was significantly higher than that of healthy subjects (P0.05), GM-CSF and M-CSF expression level in patients with cervical cancer was significantly higher than that of CIN Patients (P0.05). The expression level of SCC-Ag in patients with cervical cancer was significantly higher than that of CIN patients and healthy subjects (P0.05).M-CSF, GM-CSF, G-CSF, SCC-Ag in the diagnosis of cervical cancer were high specificity, sensitivity and M-CSF diagnosis, positive and negative predictive values were higher than those of SCC-Ag, M-CSF and SCC-Ag combined diagnosis conclusion the application of SCC-Ag. alone is higher than the level of the further research of HGFs may be a new way to find new tumor markers of cervical cancer, especially with M-CSF as a good marker of cervical cancer and CIN potential, can be used as a possible factor in early diagnosis of cervical cancer and CIN.

【作者单位】：佛山市妇幼保健院妇科;
【基金】：广东省医学科研基金立项课题(编号:A2014703)
【分类号】：R737.33

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