腹腔与静脉血中生化标志物的比值对输卵管妊娠破裂的诊断作用

发布时间：2018-04-17 18:00

  本文选题：输卵管妊娠 + 糖类抗原　； 参考：《上海交通大学学报(医学版)》2015年03期

【摘要】：目的分析输卵管妊娠患者腹腔血与静脉血清中糖类抗原125(CA125)、β-人绒毛膜促性腺素(β-h CG)、孕酮(P)、肌酸激酶(CK)和血管内皮生长因子(VEGF)含量及其比值,分析各指标与不同类型输卵管妊娠间的关系,寻找早期诊断输卵管妊娠破裂的生化标志物。方法测定322例输卵管妊娠患者静脉血清及腹腔血中CA125、β-h CG、P、CK和VEGF的含量,计算腹腔血与静脉血清中各标志物的比值(Rv/p),绘制受试者工作特征曲线(ROC曲线)并确定各项值诊断输卵管妊娠破裂型的最佳界值,评价其诊断输卵管妊娠破裂的灵敏度和特异度。结果 1CA125v、β-h CGv、Pv、CKv、VEGFv诊断输卵管妊娠破裂型的ROC曲线下面积(AUCROC)分别为0.528、0.674、0.570、0.643和0.542。2CA125p、β-h CGp、Pp、CKp、VEGFp诊断输卵管妊娠破裂型的AUCROC分别为0.896、0.595、0.656、0.586和0.682。3Rv/p-CA125、Rv/p-(β-h CG)、Rv/p-P、Rv/p-CK和Rv/p-VEGF诊断输卵管妊娠破裂型的AUCROC分别为0.883、0.757、0.607、0.628和0.598。4当CA125p400.15 U/m L时,其诊断输卵管妊娠破裂的灵敏度为73.68%,特异度达92.83%。5当Rv/pCA12515.20时,其诊断输卵管妊娠破裂的灵敏度和特异度分别为73.68%和89.81%。结论当CA125p400.15 U/m L或Rv/p-CA12515.20时可诊断为输卵管妊娠破裂型,而CA125p400.15 U/m L的特异度更高。
[Abstract]:Objective to analyze the contents and ratio of serum carbohydrate antigen 125 (CA125), 尾 -human chorionic gonadotropin (尾 -h CGN), progesterone (PRP), creatine kinase (CK) and vascular endothelial growth factor (VEGF) in serum of patients with tubal pregnancy.In order to find the biochemical markers for early diagnosis of tubal pregnancy rupture, the relationship between each index and different types of tubal pregnancy was analyzed.Methods the contents of CA125, 尾 -h CGTP-CK and VEGF in plasma of 322 patients with tubal pregnancy were measured.The ratio of serum markers in peritoneal blood and vein was calculated, and the operating characteristic curve and ROC curve were plotted. The best boundary value for diagnosis of tubal pregnancy rupture type was determined, and the sensitivity and specificity of diagnosis of tubal pregnancy rupture were evaluated.缁撴灉 1CA125v,尾-h CGv,Pv,CKv,VEGFv璇婃柇杈撳嵉绠″�婂�犵牬瑁傚瀷鐨凴OC鏇茬嚎涓嬮潰绉，

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