GnRH激动剂长效剂型和短效剂型在长方案中的应用比较

发布时间：2018-04-18 00:08

本文选题：GnRH激动剂(GnRH-a) + 长方案　；参考：《生殖与避孕》2015年06期

【摘要】：目的:探讨比较GnRH激动剂(GnRH-a)长效剂型和短效剂型在长方案中的临床应用效果。方法:将IVF-ET/ICSI治疗的长方案患者按照GnRH-a的不同剂型分为长效组(A组)和短效组(B组),比较A、B组间垂体降调节效果、促排卵过程及妊娠结局。结果:A组促性腺激素(Gn)总量、Gn使用天数、hCG注射日P、P/E2、子宫内膜厚度、平均获卵数、受精率及中、重度卵巢过度刺激综合征(OHSS)发生率高于B组,差异有统计学意义(P0.05);B组hCG注射日LH、E2、OHSS取消率、优质胚胎率、流产率较A组高,差异有统计学意义(P0.05)。移植胚胎数、移植妊娠率、着床率、宫外妊娠率比较组间无显著差异。结论:在控制性超促排卵(COH)长方案中应用GnRH-a长、短效2种剂型均可获得较满意的垂体降调节效果,虽各有利弊,但并不影响妊娠结局。
[Abstract]:Objective: to compare the clinical effects of GnRH agonist GnRH-a in long-term regimen.Methods: according to the different dosage forms of GnRH-a, the patients treated with IVF-ET/ICSI were divided into two groups: group A (long acting group) and group B (short effect group). The effects of pituitary hyporegulation, ovulation promotion and pregnancy outcome were compared between group A and group B.Results the total amount of gonadotropin Gnn in group A was higher than that in group B on the day of hCG injection. The thickness of endometrium, the average number of eggs obtained, the fertilization rate and the incidence of moderate and severe ovarian hyperstimulation syndrome (OHSS) were higher than those in group B.The difference was statistically significant (P 0.05). The cancellation rate of hCG, the rate of high quality embryos and the rate of abortion in group B were higher than those in group A, and the difference was statistically significant (P 0.05).There was no significant difference in the number of embryos transferred, pregnancy rate, implantation rate and extrauterine pregnancy rate between the two groups.Conclusion: the application of GnRH-a long and short effect in the treatment of controlled hyperstimulation of ovulation can obtain satisfactory hypophysis regulation effect, although it has both advantages and disadvantages, it does not affect the outcome of pregnancy.
【作者单位】：中南大学湘雅医学院生殖与干细胞工程研究所;中信湘雅生殖与遗传专科医院;
【分类号】：R714.8

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