多囊卵巢综合征患者血清VEGF及PEDF与卵巢过度刺激综合征的关系

发布时间：2018-04-18 04:09

  本文选题：血管内皮生长因子 + 色素上皮衍生因子　； 参考：《现代妇产科进展》2015年05期

【摘要】：目的:探讨多囊卵巢综合征(PCOS)患者控制性超促排卵过程中血清血管内皮生长因子(VEGF)及色素上皮衍生因子(PEDF)与卵巢过度刺激综合征(OHSS)发生的关系及其预测价值。方法:回顾分析行体外受精/卵细胞胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)PCOS患者52例,其中中、重度OHSS 19例,轻度或无OHSS者33例。ELISA法检测患者HCG日、取卵日及移植日的血清VEGF及PEDF水平,探讨VEGF和PEDF与OHSS发生的关系及其对OHSS的预测价值。结果:中、重度OHSS患者HCG日、取卵日及移植日的VEGF水平均高于轻度或无OHSS患者(P0.05);血清PEDF及VEGF比值均明显低于轻度或无OHSS患者(P0.05)。取卵日VEGF≥168.52pg/ml对中重度OHSS预测的灵敏的为89.5%,移植日PEDF/VEGF≤8.16对中重度OHSS预测的特异度为90.9%。结论:中重度OHSS患者的血清VEGF水平较轻度或无OHSS组中水平明显升高,且血清VEGF水平及PEDF/VEGF对OHSS的发生均有预测价值。
[Abstract]:Objective: to investigate the relationship between serum vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDFF) and OHSS in patients with polycystic ovary syndrome (PCOS) during controlled hyperstimulation.Methods: a total of 52 patients with IVF / ICSI-ET-PCOS underwent IVF / ICSI-ETSI-PCOS in vitro fertilization / oocyte intracytoplasmic sperm injection (IVF / ICSI-ET-PCOS), including 19 cases of moderate and severe OHSS and 33 cases of mild or no OHSS.The serum levels of VEGF and PEDF were measured on the day of egg collection and transplantation to investigate the relationship between VEGF, PEDF and OHSS and their predictive value for OHSS.Results: the level of VEGF in patients with moderate and severe OHSS on HCG day, egg collection day and transplantation day was higher than that in mild or non- patients, and the ratio of serum PEDF and VEGF was significantly lower than that in patients with mild or no OHSS.The sensitivity of VEGF 鈮，

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