重视与遗传相关的卵巢癌

发布时间：2018-04-18 22:14

  本文选题：遗传性 + 家族性　； 参考：《西安交通大学学报(医学版)》2017年05期

【摘要】：约20%~25%上皮性卵巢癌的发生与遗传因素相关。遗传相关的卵巢癌包括遗传性卵巢癌和家族性卵巢癌。肿瘤的遗传学特性和基因检测技术的发展,使得人们可以通过家族中的先证者检出与肿瘤相关的致病突变基因,找出其他携带有高危致病突变基因的家族成员,并进行相应的早期干预,实现肿瘤的早期预防和发现。本文对与遗传相关的卵巢癌的遗传基础、疾病特点、突变基因的检测方法、先证者的处理、现阶段面临的问题及高危个体的疾病预防等方面进行综述,强调在临床工作中重视与遗传相关的卵巢癌,找出先证者并对其亲属的患病风险进行综合评估并给出个体化的指导意见,践行精准医学理念。
[Abstract]:About 20% of epithelial ovarian cancer is associated with genetic factors.Hereditary ovarian cancer includes hereditary ovarian cancer and familial ovarian cancer.With the development of genetic characteristics and gene detection techniques, it is possible to detect tumor-related mutagenesis genes and other family members carrying high-risk pathogenicity mutation genes through probands in the family.And carry on the corresponding early intervention to realize the early prevention and discovery of tumor.In this paper, the genetic basis, disease characteristics, detection methods of mutant genes, treatment of proband, problems faced at present and disease prevention of high-risk individuals are reviewed.The emphasis is placed on the importance of genetic related ovarian cancer in clinical work, the identification of proband, the comprehensive assessment of their relatives' risk, and the individualized guidance, so as to practice the concept of precision medicine.
【作者单位】： 西安交通大学第一附属医院妇产科;
【分类号】：R737.31
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本文编号：1770308