高纯度人尿促卵泡素与基因重组促卵泡素对超促排卵周期影响比较的Meta分析

发布时间：2018-04-19 14:33

本文选题：促卵泡素 + 人尿　；参考：《中国全科医学》2015年29期

【摘要】：目的系统评价高纯度人尿促卵泡素应用于超促排卵周期的临床疗效。方法计算机检索Pub Med、The Cochrane Library(2014年第7期)、Web of Science、EMBase、中国生物医学文献数据库、中国知网、维普和万方数据库,检索时限为从建库至2014年7月。收集试验组采用高纯度人尿促卵泡素进行超促排卵治疗,对照组采用基因重组促卵泡素进行超促排卵治疗的随机对照试验(RCT)或临床对照试验(CCT)。对纳入文献进行质量评价和数据提取,采用Rev Man 5.2软件对两组临床妊娠率、活产率、成熟卵数、获卵数、超促排卵刺激天数进行分析。结果共纳入10篇RCT,4 784例患者。两组临床妊娠率、活产率、成熟卵数、获卵数、超促排卵刺激天数比较,差异均无统计学意义〔OR=1.01,95%CI(0.90,1.14),P=0.83;OR=1.04,95%CI(0.91,1.19),P=0.56;MD=-0.21,95%CI(-0.80,0.38),P=0.49;MD=-0.12,95%CI(-0.82,0.58),P=0.73;MD=-0.40,95%CI(-0.91,0.11),P=0.12〕。敏感性分析结果显示,两组获卵数和超促排卵刺激天数与原结果基本一致,具有较好的稳定性。漏斗图左右呈大致对称,存在发表偏倚的可能性较小。结论高纯度人尿促卵泡素在超促排卵周期中的临床疗效与基因重组促卵泡素相当。但由于受纳入文献数量和质量的限制,有待开展更多高质量、多中心研究加以验证。
[Abstract]:Objective to evaluate the clinical effect of high-purity human urinary follicle stimulating hormone (HUA) in hyperstimulation of ovulation cycle.Methods the Cochrane Library (issue 7 of 2014), China Biomedical Literature Database, China knowledge Network, Weip and Wanfang databases were searched by computer. The retrieval time was from the establishment of the database to July 2014.High purity human urinary follicle stimulating hormone was used for hyperstimulation of ovulation, while the control group was treated with recombinant follicle stimulating hormone (RCTT) or clinical controlled trial (CCT).The quality evaluation and data extraction were carried out by using Rev Man 5.2 software. The clinical pregnancy rate, live birth rate, number of mature eggs, number of eggs obtained and days of stimulation of hyperstimulation of ovulation were analyzed by Rev Man 5.2 software.Results A total of 4784 patients were included in 10 RCTs.The results of sensitivity analysis showed that the number of eggs obtained and the days of hyperstimulation of ovulation stimulation in the two groups were basically consistent with the original results and had good stability.The funnel graph is approximately symmetrical on the left and right, and the possibility of publication bias is small.Conclusion the clinical efficacy of high purity human urinary follicle stimulating hormone in hyperstimulation cycle is similar to that of recombinant follicle stimulating hormone.However, due to the limitation of the quantity and quality of the literature included, more high-quality studies are needed.
【作者单位】：四川省成都市锦江区妇幼保健院;四川大学循证医学中心;新疆医科大学第一附属医院妇科生殖助孕中心;
【基金】：新疆维吾尔自治区自然科学基金资助项目(2013211A087)
【分类号】：R714.8

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