周疗在宫颈癌同步放化疗中的作用

发布时间：2018-04-20 05:38

本文选题：子宫颈肿瘤 + 同步放化疗　；参考：《重庆医学》2015年06期

【摘要】：目的评价周疗在宫颈鳞癌同步放化疗中的作用。方法对该院2003年1月至2007年10月收治的Ⅲb期宫颈鳞癌168例分为两组,其中观察组86例采用紫杉醇+顺铂周疗+同步放疗,对照组82例采用紫杉醇+顺铂3周疗法+同步放疗,比较两组的5年生存率和不良反应。结果观察组5年生存率为52.3%(45/86),对照组为42.7%(35/82),两组比较差异无统计学意义(P0.05);观察组有效率(CR+PR)为94.2%(81/86),对照组为92.7%(76/82),两组比较差异无统计学意义(P0.05);观察组Ⅲ度以上骨髓抑制发生率为9.3%(8/86),对照组为20.7%(17/82),两组比较差异有统计学意义(P0.05);观察组Ⅲ度以上胃肠道反应发生率为8.1%(7/86),对照组为19.5%(16/82),两组比较差异有统计学意义(P0.05);观察组放疗完成时间(54.72±4.76)d,对照组(61.12±6.71)d,两组比较差异有统计学意义(P0.05)。结论宫颈鳞癌同步放化疗中周疗较3周疗法疗效不良反应更少,疗效相当。
[Abstract]:Objective to evaluate the role of weekly therapy in concurrent chemoradiotherapy of cervical squamous cell carcinoma. Methods 168 cases of stage III B squamous carcinoma in the hospital from January 2003 to October 2007 were divided into two groups, of which 86 cases in the observation group were treated with paclitaxel + cisplatin plus concurrent radiotherapy, and 82 cases in the control group were treated with paclitaxel + cisplatin 3 week therapy plus synchronous radiotherapy, and the 5 year survival rate of the two groups was compared. The 5 year survival rate of the observation group was 52.3% (45/86), the control group was 42.7% (35/82), the two groups had no significant difference (P0.05), the effective rate (CR+PR) was 94.2% (81/86), the control group was 92.7% (76/82), and the two groups had no statistical significance (P0.05), and the incidence of myelosuppression in the observation group was 9.3% (8/86), and that of the observation group was 9.3% (8/86), and In the group of 20.7% (17/82), the difference between the two groups was statistically significant (P0.05); the incidence of gastrointestinal reaction in the observation group was 8.1% (7/86) and 19.5% (16/82) in the control group (P0.05); the radiotherapy completion time of the observation group was (54.72 + 4.76) d, and the control group (61.12 + 6.71) d, and the two groups were statistically significant (P0). .05). Conclusion weekly treatment of cervical squamous cell carcinoma with concurrent chemoradiotherapy is less effective than the 3 week treatment.

【作者单位】：重庆市肿瘤研究所妇瘤科;
【分类号】：R737.33

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