消支助孕汤联合干扰素栓治疗解脲支原体感染性不孕的临床观察

发布时间：2018-04-20 11:15

本文选题：支原体感染 + 不孕　；参考：《中国中西医结合杂志》2017年12期

【摘要】：目的观察消支助孕汤联合重组人干扰素α-2a栓阴道外用治疗支原体感染性不孕的临床疗效。方法选取支原体阳性不孕患者226例,随机分为治疗组和对照组,治疗组应用消支助孕汤口服联合重组人干扰素α-2a栓阴道外用;对照组应用多西环素口服加重组人干扰素α-2a栓阴道外用。观察两组解脲支原体(Uu)转阴率,治疗前后抗精子抗体(AsAb)、抗子宫内膜抗体(AEMAb)变化,妊娠率及不良反应情况。结果治疗组妊娠率67.8%(80/118),明显优于对照组[37.9%(41/108)],差异有统计学意义(χ2=20.18,P0.01);治疗组Uu转阴率为92.4%(109/118)、流产率2.5%(2/80),对照组Uu转阴率93.5%(101/108)、流产率7.3%(3/41),两组比较,Uu转阴率及流产率差异均无统计学意义(P0.05);治疗后两组AsAb和AEMAb阳性率较治疗前均下降(P0.05),且治疗组阳性率明显低于对照组(P0.05),治疗组转阴率优于对照组(P0.05);治疗后抗体阴性者妊娠率78.5%(106/135),明显优于抗体阳性者[16.5%(15/91)],差异有统计学意义(χ~2=84.10,P0.01);抗体阴性者流产率1.9%(2/106),低于抗体阳性者[20.0%(3/15)],差异有统计学意义(χ~2=10.88,P0.05)。结论消支助孕汤口服联合重组人干扰素α-2a栓阴道外用治疗支原体感染不孕患者,能有效清除Uu,降低自身免疫激活状态,从而提高了妊娠率,降低了流产率。
[Abstract]:Objective to observe the clinical effect of Xiaoyingren decoction (XYT) combined with recombinant human interferon 伪-2a suppository for the treatment of mycoplasma infective infertility. Methods 226 cases of mycoplasma positive infertility were randomly divided into treatment group and control group. The treatment group was treated with Xiaoyinghentang orally combined with recombinant human interferon 伪 -2a suppository for external vaginal use. The control group was treated with doxycycline orally and recombinant human interferon 伪-2a suppository for vaginal use. The negative rate of Ureaplasma Urealyticum Ureaplasma Urealyticum (UU), the changes of anti-sperm antibody, anti-endometrial antibody, pregnancy rate and adverse reaction were observed before and after treatment. After treatment, the positive rates of AsAb and AEMAb in both groups were lower than those before treatment, and the positive rate of AsAb and AEMAb in the treatment group was significantly lower than that in the control group (P 0.05), the negative conversion rate in the treatment group was better than that in the control group (P 0.05), and the pregnancy rate in the patients with negative antibody after treatment was 78.5 / 135, which was significantly better than that in the antibody positive group. [16.5% 15 / 91], the difference was statistically significant (蠂 2 + 84.10% P 0.01); the abortion rate of those with negative antibody was 1.9% 10 / 106, lower than that of those with positive antibody [20.0% / 15], and the difference was statistically significant (蠂 2 10.8 8 P 0.05). Conclusion the oral administration of Xiaoyinghentang combined with recombinant human interferon 伪 -2a suppository for vaginal treatment of infertile patients with mycoplasma infection can effectively remove UU and decrease the state of autoimmune activation, thus increasing the pregnancy rate and reducing the abortion rate.
【作者单位】：河北省衡水市第四人民医院妇科;
【分类号】：R711.6

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