徐州地区39997例女性生殖道人乳头瘤病毒检测结果分析

发布时间：2018-04-20 12:30

本文选题：人乳头瘤病毒 + 徐州地区　；参考：《现代预防医学》2015年11期

【摘要】：目的了解徐州地区妇女生殖道人乳头瘤病毒(HPV)感染情况。方法采用凯普医用核酸分子杂交技术及其配套试剂对2009年2月-2012年5月于我院体检、就诊的39 997例女性行生殖道人乳头瘤病毒分型检测,分析HPV感染及亚型分布情况。结果 (1)39 997例女性中HPV阳性8 369例,阳性率20.92%;(2)其中单一感染6 305例,占阳性病例的75.34%,多重感染2 064例,占阳性病例的24.66%;单一感染与多重感染比较差异有统计学意义(χ2=5 723.03,P0.0001);(3)感染的高峰年龄为20岁以下组,感染率30.21%。随年龄增长,HPV感染率逐渐下降,51~60岁组出现HPV感染的第二个高峰,感染率为21.82%;(4)HPV高危亚型感染7 079例,低危亚型感染2 116例,两者比较差异有统计学意义,(χ2=2931.16,P0.0001);(5)随年龄的增加HPV高危亚型的感染率逐渐升高,低危亚型的感染率逐渐降低,各年龄组间单一高危型感染率差异具统计学意义,(χ2=55.45,P0.0001)。(6)21种HPV亚型均被检出,感染率排前六位的亚型为16、58、52、53、CP8304、11。其中HPV16感染率与其他各型相比差异有统计学意义,P0.0001。HPV58感染率与其他各型相比差异有统计学意义(P0.01)。结论徐州地区女性HPV感染率较高,以单一、高危型感染为主,HPV16、58、52、53是主要的感染亚型。
[Abstract]:Objective to investigate the infection of human papillomavirus (HPV) in female genital tract in Xuzhou. Methods 39 997 female patients who were examined in our hospital from February 2009 to May 2012 were examined for human papillomavirus (HPV) typing, and the distribution of HPV infection and subtype were analyzed. Results among 39 997 women, 8 369 cases were HPV positive, the positive rate was 20.92%) among them, 6 305 cases were single infection, accounting for 75.34% of positive cases, and 2 064 cases were multiple infection. There was a significant difference between single infection and multiple infection (蠂 ~ 2 + 5723.03 / P 0.0001). The peak age of infection was below 20 years old, and the infection rate was 30.21%. With the increase of age, the infection rate of HPV decreased gradually. The second peak of HPV infection was found in the group of 51 ~ 60 years old. The infection rate was 7 079 cases of high risk subtype infection and 2 116 cases of low risk subtype infection. There was a significant difference between the two groups (蠂 2 931. 16 P 0. 0001). The infection rate of high risk subtype of HPV gradually increased with age, and the infection rate of low risk subtype gradually decreased. The difference of infection rate of single high risk type among different age groups was statistically significant (蠂 2 5. 45% P 0. 0001. 621 HPV subtypes were detected. The subtype of infection rate in the first six places was 16582 / 52C / 8304 / 11. The infection rate of HPV16 was significantly higher than that of other types (P 0.0001.HPV58). Conclusion the infection rate of HPV is higher in women in Xuzhou area.
【作者单位】：江苏省徐州市妇幼保健院宫颈疾病诊治中心;
【分类号】：R737.33

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